Difference between revisions of "Category:Paramyxoviridae"

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==Morphology==
 
*Single-stranded negative-sense unsegmented RNA virus
 
*Reassortment and antigenic shift cannot occur
 
*Spike proteins include
 
**'''HN''' (Haemagglutinin and Neuraminidase)
 
**'''F''' (Fusion glycoprotein), which allows the virus to fuse directly to the plasma membrane and release its RNA
 
***F also causes syncitium to form, which aids diagnosis
 
***Host antibody response to the F protein is the basis for vaccination
 
  
==Virulence==
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{{Learning |Vetstream = <p>[https://www.vetstream.com/canis/Content/Bug/bug00215.asp Canine Distemper]</p><p>[https://www.vetstream.com/canis/Content/Bug/bug00210.asp Canine Parainfluenza Virus 2]</p>}}
*Paramyxoviruses replicate in the epithelium of the upper respiratory tract as well as occasionally in the gut
 
**Sites of spike protein cleavage
 
*Virulence varies by virus, see below
 
  
==Types and Subtypes==
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[[Category:Viral Organisms]]
Paramoyxoviridae was reclassified in 2000 to include 2 subfamilies and 5 genera, of interest including:
 
*Subfamily: ''[[Paramyxovirinae]]'':
 
 
 
*Subfamily: ''[[Pneumovirinae]]''
 
 
 
==Antigenic Variation==
 
*Antigenic conservation allows some cross protection by vaccination:
 
**Conservation of major virus-specific F/HN antigens means vaccines protect against '''all isolates''' of the same virus
 
**Minor morbillivirus-specific epitopes on F allows some cross protection between '''canine distemper, measles, and rinderpest'''
 
*Antigenic "fingerprinting" is possible for some viruses based on minor variable epitopes of HN, F and NP on specific isolates as detected by monoclonal antibodies
 
**These are detected by immunostaining infected cells
 
 
 
=Other resources=
 
*[http://www.pitt.edu/~super1/lecture/lec3401/index.htm On line Paramyxoviridae lecture by P. Russell]
 
 
 
[[Category:Viruses]]
 
[[Category:To_Do_-_Clinical/Viruses]]
 

Latest revision as of 00:00, 16 June 2016



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Pages in category "Paramyxoviridae"

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