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| − | ===Deficiencies of Innate Immunity=== | + | {{frontpage |
| − | [[Image:Grey Collie Syndrome.jpg|thumb|right|150px|Appearance of a puppy with Grey Collie syndrome - Copyright Michelle Tennis & Peggy Melton]]
| + | |pagetitle =Primary Innate Immunity Deficiencies |
| − | ====Canine Cyclic Haematopoiesis====
| + | |pagebody = |
| − | *Also called '''Grey Collie Syndrome'''
| + | |contenttitle = Content |
| − | *Autosomal recessive
| + | |contentbody =<big><b> |
| − | *Insertion mutation in AP3B1 gene
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| − | *Diluted grey coat colour, stunted growth, poor wound healing
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| − | *Neutropenia every 2 weeks which lasts 3-4 days due to cyclic production of cells from [[Bone Marrow - Anatomy & Physiology|bone marrow]]
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| − | *Animals are prone to recurrent infections, mainly from the respiratory and gastrointestinal tract
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| − | **E.g. pyrexia, [[Diarrhoea|diarrhoea]], gingivitis and arthritis
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| − | *Puppies can be distinguished from other litter mates by the diluted grey colouring
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| − | *Affected puppies show symptoms such as fever, joint pain and eye, skin and respiratory infections from 8 weeks of age
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| − | *Affected animals rarely live beyond 2-3 years with most puppies dying within a few weeks of birth
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| − | ====Canine Leukocyte Adhesion Deficiency (CLAD)==== | + | <categorytree mode=pages>Primary Innate Immunity Deficiencies</categorytree> |
| − | *Occurs in Irish Setters
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| − | *Missence mutation of -Cys-36-Ser- in CD18 molecule
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| − | **CD18 is required for [[Neutrophils|neutrophil]] migration and phagocytosis
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| − | *Recurrent bacterial infection
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| − | *Neutrophilia ([[Neutrophils|neutrophils]] remain in the blood and are unable to fight infection in the tissue)
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| | | | |
| − | ====Bovine Leukocyte Adhesion Deficiency (BLAD)==== | + | |logo = Immature MDDC.png |
| − | *Occurs in Holstein cattle
| + | }} |
| − | *Missence mutation of -Asp-128-Gly in CD18 molecule
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| − | *Recurrent infection, e.g. pneumonia
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| − | [[Category:Primary Im | + | |
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| | + | [[Category:Primary Immunodeficiency|A]] |
