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This occurs in late autumn and winter, mainly between the months of August to October. Outbreaks of acute fascioliasis usually present as sudden deaths.  On examination infected animals are weak, with pale mucous membranes.  They may also have enlarged livers, and the liver surface may be cover with a fibrinous peritonitis, particularly evident on the ventral lobe. Tracts become filled with blood and degenerate hepatocytes later infiltrated with [[Eosinophils|eosinophils]], [[Lymphocytes|lymphocytes]] and replaced by fibrosis.
 
This occurs in late autumn and winter, mainly between the months of August to October. Outbreaks of acute fascioliasis usually present as sudden deaths.  On examination infected animals are weak, with pale mucous membranes.  They may also have enlarged livers, and the liver surface may be cover with a fibrinous peritonitis, particularly evident on the ventral lobe. Tracts become filled with blood and degenerate hepatocytes later infiltrated with [[Eosinophils|eosinophils]], [[Lymphocytes|lymphocytes]] and replaced by fibrosis.
      
[[Image:Fasciola hepatica.jpg|300px|thumb|right|'''Fasciola hepatica (Copyright Adam Cuerden, Wikimedia Commons) ''']]
 
[[Image:Fasciola hepatica.jpg|300px|thumb|right|'''Fasciola hepatica (Copyright Adam Cuerden, Wikimedia Commons) ''']]
    
[[Image:Fasciola hepatica - bile duct.jpg|300px|thumb|right|'''Fasciola hepatica (Copyright Flukeman, Wikimedia Commons) ''']]
 
[[Image:Fasciola hepatica - bile duct.jpg|300px|thumb|right|'''Fasciola hepatica (Copyright Flukeman, Wikimedia Commons) ''']]
      
===Subactute Fascioliasis===
 
===Subactute Fascioliasis===
This is caused by ingestion of metacercariae over a longer period of time.  Some may have migrated to the bile ducts, causing [[cholangitis]], whilst other metacercariae are migrating through the liver causing lesions similar to those present in acute fascioliasis.  The infected host may present with severe haemorrhagic anaemia, with [[hypoalbuminaemia]], rapid loss of body condition, reduced appetite, pale mucous membranes, and submandibular oedema may also be present. On examination, an enlarged liver is common and haemorrhagic tracts are usually visible on the liver surface. If left untreated, it is often fatal.  This form of fascioliasis occurs around 6-10 weeks after ingestion of the metacercariae by the host, and like acute fascioliasis occurs in late autumn and winter.
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This is caused by ingestion of metacercariae over a longer period of time.  Some may have migrated to the bile ducts, causing [[cholangitis]], whilst other metacercariae are migrating through the liver causing lesions similar to those present in acute fascioliasis.  The infected host may present with severe haemorrhagic anaemia, with [[hypoalbuminaemia]], rapid loss of body condition, reduced appetite, pale mucous membranes, and submandibular oedema may also be present. On post-mortem, an enlarged liver is common and haemorrhagic tracts are usually visible on the liver surface. If left untreated, it is often fatal.  This form of fascioliasis occurs around 6-10 weeks after ingestion of the metacercariae by the host, and like acute fascioliasis occurs in late autumn and winter.
    
===Chronic Fascioliasis===
 
===Chronic Fascioliasis===
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This is usually seen in late winter, early spring and is currently the most common fascoloiasis seen.  It occurs around 4-5 months after ingestion of the metacercariae.  Hypochromic and macrocytic anaemia and hypoalbuminaemia are common, as the adult flukes are capable of sucking up to 0.5ml of blood each day. In heavy infections, this can prove to be a severe loss.
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Infected animals may present with progressive loss of body condtion, reduced appeptite, which along with hypoalbuminaemia can result in an gaunt animal. Other common signs include pale mucous membranes, and submandibular oedema, more commonly known as 'bottle jaw.'  On biopsy the liver will have an irregular shape, distorted shape with areas of fibrous tissue replacing the cells damaged by the migrating flukes. The bile ducts appear dilated, dark and calcified, and it is often possible to express numerous numbers of adult flukes from within the ducts.  Chronic cholagitis is common, resulting in a pipe stem appearance in cattle.
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======Gross======
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*[[Liver - Anatomy & Physiology|liver]] is reduced in size, unevenly
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**left lobe is most severely affected with atrophy of the extremities
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*hypertrophy may occur in some cases
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**dorsal lobe
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**this changes size and distorts shape of [[Liver - Anatomy & Physiology|liver]]
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*the surface will be uneven with areas of fibrous tissue replacing the cells damaged by the migrating flukes
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*bile ducts
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**prominent thick protruding white bile ducts on the '''visceral surface''' spreading from the hilus to the left lobe
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**the bile ducts are dilated, black, and calcified on '''cut surface'''
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**numerous adult flukes can be expressed from the bile ducts
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**chronic cholangitis
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**''''pipe stem'''' appearance in cattle because bile ducts are very much thickened and often calcified
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*bile
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**dark brown, thick, and gritty in consistency
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NB: the fibrosis which occurs in the chronic stage is realted only partly to the healing of the migratory tracts and the rest may be related to the development of immunity and rechallenge
      
======Microscopically======
 
======Microscopically======
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