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Gastric Ulceration - Horse (view source)

Revision as of 11:17, 30 July 2010

938 bytes removed ,  11:17, 30 July 2010
→‎Antibiotics
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benzimidazole anthelmintic, fenbendazole, for treatment of gastric ulcer disease in the horse. At present there is insufficient scientific evidence to support the use of other benzimidazole compounds.(EGUC)
 
benzimidazole anthelmintic, fenbendazole, for treatment of gastric ulcer disease in the horse. At present there is insufficient scientific evidence to support the use of other benzimidazole compounds.(EGUC)
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===Antibiotics===
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While there is little doubt that H2 blockers and proton pump inhibitors suppress acid production and induce healing in humans, there is an alarming rate of recurrence (50% over 6 months and 95% over 2 years).
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Recent reports indicating that Helicobacter pylori plays a pivotal role in the disease process led to antibiotic therapies and to the use of antibiotics in combination with acid-suppression therapies.
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When compared to acid suppression alone, these combination therapies demonstrate greater short-term efficacy and recurrence rates that were reduced by 80%. In addition to its superior acid-suppression properties, omeprazole has been shown to have a bacteriostatic effect on H. pylori.
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Numerous strategies have been developed to combine antibiotics with antisecretory compounds to treat the human syndromes. Omeprazole and amoxicillin have been shown to be the most effective and produce few side effects.(EGUC)
       
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