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Fasciolosis (view source)

Revision as of 18:08, 5 August 2010

1,133 bytes removed ,  18:08, 5 August 2010
→‎Pathology
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**Gamma  glutamyl transpeptidase released by damaged cells  
 
**Gamma  glutamyl transpeptidase released by damaged cells  
 
**Ulceration  and haemorrhage of bile duct → epithelial hyperplasia and increased  mucosal permeability
 
**Ulceration  and haemorrhage of bile duct → epithelial hyperplasia and increased  mucosal permeability
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*'''Anaemia'''
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**250  flukes → up to 50ml of blood loss daily → 10 times increase in rate of  erythropoiesis → normochronic anaemia until iron stores are exhausted →  hypochromic anaemia.
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*'''Hypoalbuminaemia'''
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**Albumin (and other plasma proteins) lost into bile duct  because of
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#Whole blood loss
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#Increased  epithelial permeability
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** → Increased catabolic rate by  2.5x → increased nitrogen loss via urine
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**The effects  seen depend on the magnitude of nitrogen loss
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#There is  no obvious effect (although animal is still in abnormal physiological  state)
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#Reduced weight-gain and/or wool growth and/or  milk production
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#Loss of body tissue (i.e. weight-loss);  hypoalbuminaemia → reduced plasma oncotic pressure → oedema
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This is usually seen in late winter,  early spring and  is currently the most common fascoloiasis seen.  It  occurs around 4-5  months after ingestion of the metacercariae.  Hypochromic and macrocytic  anaemia and hypoalbuminaemia are common, as  the adult flukes are  capable of sucking up to 0.5ml of blood each day.  In heavy infections,  this can prove to be a severe loss.
       
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