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42 bytes removed ,  13:39, 28 September 2010
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==Monocyte development==
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==Monocytes==
 
[[Monocytes|Monocytes]] develop from the same precursor as [[Neutrophils|neutrophils]] the [[Haematopoiesis - Overview#Colony Forming Units|CFU-GM]]. This then differentiates into the [[Haematopoiesis - Overview#Colony Forming Units|CFU-M]] under the influence of GM-CSF, IL-3 and M-CSF.
 
[[Monocytes|Monocytes]] develop from the same precursor as [[Neutrophils|neutrophils]] the [[Haematopoiesis - Overview#Colony Forming Units|CFU-GM]]. This then differentiates into the [[Haematopoiesis - Overview#Colony Forming Units|CFU-M]] under the influence of GM-CSF, IL-3 and M-CSF.
===Stages===
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===Stages:===
 
====Monoblast====
 
====Monoblast====
 
First stage after cell has differentiated into the [[Haematopoiesis - Overview#Colony Forming Units|CFU-M]].
 
First stage after cell has differentiated into the [[Haematopoiesis - Overview#Colony Forming Units|CFU-M]].
 
====Promonocyte====
 
====Promonocyte====
 
Cell has a large nucleus and basophilic cytoplasm and consists of two populations:- One rapidly dividing and the other slowly dividing (acting as a reservoir).
 
Cell has a large nucleus and basophilic cytoplasm and consists of two populations:- One rapidly dividing and the other slowly dividing (acting as a reservoir).
 
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====Monocyte====
====[[Monocytes|Monocyte]]====
   
Monocytes are incapable of mitosis and enter circulation. They have a large kidney shaped nucleus with a slightly basophilic cytoplasm.
 
Monocytes are incapable of mitosis and enter circulation. They have a large kidney shaped nucleus with a slightly basophilic cytoplasm.
====[[Macrophages|Macrophage]]====
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====Macrophage====
 
Once the monocyte has entered tissue it differentiates into a [[Macrophages|macrophage]].
 
Once the monocyte has entered tissue it differentiates into a [[Macrophages|macrophage]].
   
===Dendritic cells===
 
===Dendritic cells===
 
Develop from the monoblast under the stimualtion of GM-CSF and IL-4 into an immature dendritic cell. This then develops into the mature dendritic cell under stimulation of TNF-α.
 
Develop from the monoblast under the stimualtion of GM-CSF and IL-4 into an immature dendritic cell. This then develops into the mature dendritic cell under stimulation of TNF-α.
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