Difference between revisions of "Louping Ill"
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| Line 1: | Line 1: | ||
| − | {{unfinished}} | + | {{unfinished}} |
| − | ====Hosts==== | + | ==== Hosts ==== |
| − | *Sheep | + | |
| − | *Grouse | + | *Sheep |
| − | *Hares | + | *Grouse |
| − | *Deer elk | + | *Hares |
| − | *Small rodents | + | *Deer elk |
| − | *Ticks (eg. ''Ixodes ricinus'') | + | *Small rodents |
| + | *Ticks (eg. ''Ixodes ricinus'') | ||
*Man | *Man | ||
| − | ====Pathogenesis==== | + | ==== Pathogenesis ==== |
| − | *First phase: | + | |
| − | **Pyrexia with virus in '''macrophages''' | + | *First phase: |
| − | **Recovery | + | **Pyrexia with virus in '''macrophages''' |
| − | *Second phase: | + | **Recovery |
| − | **Second replication in '''Purkinje cells''' of the cerebellum and '''motor nuclei''' of the brain stem | + | *Second phase: |
| − | **Trembling, torticollis, and irregular gait | + | **Second replication in '''Purkinje cells''' of the cerebellum and '''motor nuclei''' of the brain stem |
| − | **In grouse: starvation | + | **Trembling, torticollis, and irregular gait |
| + | **In grouse: starvation | ||
**In man: flu-like symptoms can be followed by coma, but recovery normal | **In man: flu-like symptoms can be followed by coma, but recovery normal | ||
| − | ====Epidemiology==== | + | ==== Epidemiology ==== |
| − | *Reservoir host: '''Ticks (''Ixodes ricinus'')''' | + | |
| − | **Passed to host by '''saliva''' | + | *Reservoir host: '''Ticks (''Ixodes ricinus'')''' |
| − | **Virus can be spread '''between ticks''' when co-feeding on small rodents | + | **Passed to host by '''saliva''' |
| + | **Virus can be spread '''between ticks''' when co-feeding on small rodents | ||
*Spread mirrors seasonal tick activity | *Spread mirrors seasonal tick activity | ||
| − | ====Diagnosis==== | + | ==== Diagnosis ==== |
| − | *Clinical signs | + | |
| + | *Clinical signs | ||
*PM: virus isolation and histopathology of brain tissue | *PM: virus isolation and histopathology of brain tissue | ||
| − | ====Control==== | + | ==== Control ==== |
| − | *Sheep dipping in '''acaracides''' (vector control) | + | |
| − | *'''Inactivated vaccines''' in late pregnancy can '''boost maternal antibody''' | + | *Sheep dipping in '''acaracides''' (vector control) |
| − | **Lambs inoculated | + | *'''Inactivated vaccines''' in late pregnancy can '''boost maternal antibody''' |
| + | **Lambs inoculated >4 months of age | ||
*Human vaccination where at risk | *Human vaccination where at risk | ||
| − | [[Category:Flaviviruses]][[Category: | + | |
| − | [[Category:To_Do_-_Clinical/Viruses]] | + | [[Category:Flaviviruses]] [[Category:Sheep_Viruses]] [[Category:Avian Viruses]] [[Category:Zoonoses]] [[Category:Rodents]] [[Category:To_Do_-_Clinical/Viruses]] [[Category:Neurological_Diseases_-_Sheep]] |
| − | [[Category: | ||
Revision as of 16:59, 24 January 2011
 |
This article is still under construction. |
Hosts
- Sheep
- Grouse
- Hares
- Deer elk
- Small rodents
- Ticks (eg. Ixodes ricinus)
- Man
Pathogenesis
- First phase:
- Pyrexia with virus in macrophages
- Recovery
- Second phase:
- Second replication in Purkinje cells of the cerebellum and motor nuclei of the brain stem
- Trembling, torticollis, and irregular gait
- In grouse: starvation
- In man: flu-like symptoms can be followed by coma, but recovery normal
Epidemiology
- Reservoir host: Ticks (Ixodes ricinus)
- Passed to host by saliva
- Virus can be spread between ticks when co-feeding on small rodents
- Spread mirrors seasonal tick activity
Diagnosis
- Clinical signs
- PM: virus isolation and histopathology of brain tissue
Control
- Sheep dipping in acaracides (vector control)
- Inactivated vaccines in late pregnancy can boost maternal antibody
- Lambs inoculated >4 months of age
- Human vaccination where at risk