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Muscles Degenerative - Pathology (view source)

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===Porcine ~~stress syndrome~~===

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===[[Porcine Stress Syndrome]]===

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*'''Malignant hyperthermia'''

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*Pigs, dogs, humans

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*Possibly a cellular defect resulting in high intacellular calcium ion concentration

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**-> Activates myofibrillar ATPase -> rapid intracellular glycolysis -> increase in body heat -> denature protein -> cell death -> leakage of cellular content -> oedema

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*Grossly:

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**Muscles are pale, soft and exudative

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*Histologically:

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**Segmental hypercontraction

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**Monophasic, multifocal [[Muscles Degenerative - Pathology#Necrosis|segmental necrosis]]

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*Inherited

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*Triggered by halothane anaesthesia, stress of handling, transportation or slaughter

==Neuromuscular junction diseases==

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