Difference between revisions of "Bones Degenerative - Pathology"

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===Osteoporosis (Atrophy)===
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===[[Osteoporosis]] (Atrophy)===
 
 
*Lesion, not a disease
 
*Reduction in bone mass due to reduced osteoid (bone atrophy)
 
*Bone resorption exceeds formation -> pathological loss of bone
 
*Resorbed from:
 
**Trabeculae, preserving the weight bearing ones until last
 
**Endosteal surface of cortical bone
 
**Along vascular channels
 
*Longitudinal section
 
**Fewer thin trabeculae
 
**Enlarged medulla
 
**Thin, porous cortex
 
*Bone which remains is normally mineralised
 
*Can be localised or generalised*Caused by:
 
**Starvation - in farm animals due to protein and energy deficiency
 
**Nutritional deficiency (calcium) and hypocalcaemia -> bone resorption
 
**Senility
 
***Physiological loss of skeletal mass with age
 
***May be excessive in some individuals
 
***Histologically - dead [[Bones - Anatomy & Physiology|osteocytes and empty lacunea]]
 
**Physical inactivity (disuse) - muscular inactivity and reduced weight bearing, e.g. during limb casting
 
**Glucocorticoids
 
**[[:Category:Enteritis, Parasitic|Intestinal parasitism]] - in ruminants, malabsorption due to severe infestation
 
**[[Congenital and Neonatal Disease - Pathology#Copper Deficiency|Copper deficiency]] - in lambs, calves, foals, pigs and dogs -> brittle bones
 
*May be reversed in young growing animals
 
 
 
  
 
===Osteosis===
 
===Osteosis===
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*Associated with [[Joints Degenerative - Pathology#Calve Legg-Perthe's disease|Calve-Legg Perthe's disease]]
 
*Associated with [[Joints Degenerative - Pathology#Calve Legg-Perthe's disease|Calve-Legg Perthe's disease]]
  
 
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[[Category:Bones - Degenerative Pathology]]
 
===Bone cysts===
 
===Bone cysts===
 
[[Image:Bone cysts dog.jpg|right|thumb|100px|<small><center>Bone cysts (Image sourced from Bristol Biomed Image Archive with permission)</center></small>]]
 
[[Image:Bone cysts dog.jpg|right|thumb|100px|<small><center>Bone cysts (Image sourced from Bristol Biomed Image Archive with permission)</center></small>]]
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*Radiography is essential to help differentiate with cavity of a neoplasm
 
*Radiography is essential to help differentiate with cavity of a neoplasm
  
 
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[[Category:Bones - Degenerative Pathology]]
 
===Calcium hydroxylapatite deposition disease===
 
===Calcium hydroxylapatite deposition disease===
  
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*[[More on Calcium hydroxylapatite deposition disease|More about Calcium hydroxylapatite deposition disease]]
 
*[[More on Calcium hydroxylapatite deposition disease|More about Calcium hydroxylapatite deposition disease]]
  
 
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[[Category:Bones - Degenerative Pathology]]
 
===Physeal dysplasia with slipped capital femoral epiphysis===
 
===Physeal dysplasia with slipped capital femoral epiphysis===
  
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*[[More about Physeal dysplasia]]
 
*[[More about Physeal dysplasia]]
  
 
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[[Category:Bones - Degenerative Pathology]]
[[Category:Musculoskeletal System - Pathology]]
 

Revision as of 11:56, 3 March 2011


Bones and Cartilage - Metabolic diseases

Bones and Cartilage - Fractures

Osteoporosis (Atrophy)

Osteosis

  • Also called Aseptic necrosis or Ischaemic necrosis
  • Degeneration and necrosis of osseous tissue
  • Due to bone marrow pressure and ischaemia resulting from
  • Grossly:
    • Necrotic bone difficult to recognise
    • Sometimes, periosteum becomes dry, dull and detaches easily
    • On longitudinal section
      • Yellow-white necrotic bone
      • Scattered cancellous and endosteal bone
  • Histologically:
  • Necrotic bone is slowly resorbed, sequstered or covered by new woven bone
  • Persists
  • May not be detected radiographically
  • Associated with Calve-Legg Perthe's disease

Bone cysts

Bone cysts (Image sourced from Bristol Biomed Image Archive with permission)
  • May be seen radiographically
  • Must be distinguished from neoplasia
  • Expansile lytic masses
  • Do not appear aggressive
  • Subchondral cysts
  • Simple cysts
  • Aneurysmal bone cysts
    • Expansie lesions
    • Arise from disturbance of vascular tissue of bone marrow
    • Grossly:
      • Appear as blood filled sponge
      • Spaces separated by fibrous trabeculae
    • Histologically:
      • Proliferation of undifferentiated mesenchymal cell with multinucleated osteoclast-like cells
      • Haemorrhage and haemosiderosis
  • Radiography is essential to help differentiate with cavity of a neoplasm

Calcium hydroxylapatite deposition disease

Physeal dysplasia with slipped capital femoral epiphysis

  • Slipped capital femoral epiphysis seen in dogs, foals and calves
  • Associated with severe trauma
  • Pigs – manifestation of osteochondrosis with only minimal trauma required
  • Most common type of physeal fracture in small animals and the proximal femur is the most common site
  • In horses, physeal dysplasia is synonymus with physitis
  • More about Physeal dysplasia