Difference between revisions of "Non-Infectious Arthritis"

Revision as of 16:19, 3 March 2011

Occurs in dogs
Clinical signs:
- Anaemia
- Thrombocytopaenia
- Polymyositis
- Glomerulonephritis

@@ Line 1: / Line 1: @@
 *No causative agent has been found
 *Seem to be immune-mediated diseases
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 ===Erosive===
-====Rheumatoid arthritis====
+====[[Rheumatoid Arthritis]]====
-*Occurs in the dog, mainly smaller breeds
-*Uncommon
-*Progressive erosive polyarthritis
-*Mostly involves elbows, stifles, carpal and tarsal joints
-*Grossly:
-**Marked villus hypertrophy of synovial membrane
-**Cartilage erosion
-**[[Musculoskeletal Terminology - Pathology|Pannus and periarticular osteophyte]] formation
-**In severe cases ankylosis
-*Histologically:
-**Hyperplasia of lining cells
-**Proliferative synovitis
-**Synovial membrane has fibrin deposits
-**Lymphoid and plasma cell infiltration
-**Surrounding haemorrhagic areas
-**Macrophages containing [[Pigmentation - Pathology#Haemosiderin|haemosiderin]]
-**Connective tissue may contain foci of necrosis
-**Areas of erosion of peripheral articular cartilage and underlying subchondral bone
-*Pathogenesis:
-**May involve deposition of immune complexes within joints
-**Substances degrading cartilage are released by synovial cells and macrophages involved in pannus formation