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CNS Degenerative Diseases - Pathology
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==[[Cognitive Dysfunction Syndrome]] ==
==[[Cognitive Dysfunction Syndrome]] ==
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(CDS)
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* CDS causes signs of senility.
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* Increasing numbers of dogs and cats are suffering from CDS.
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** Prevalence is similar to that seen in humans: an 85 year-old human is roughly equivalent to a 15 year-old cat, and a 13-14 year-old dog.
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*** Aging in dogs id breed specific.
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===Pathology===
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* A number of changes are seen in the brains of geriatric animals which may cause the signs of CDS.
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** Vascular insufficiency leads to:
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*** Hypoxia
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*** Increased free redical production
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*** Deposition of amyloid plaques
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*** Modification of other brain proteins
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===Treatment===
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* There are no published studies related to treatment of CDS in animals.
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* Potential therapies include:
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** Dietary modification
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*** Diets are enriched with antioxidants, vitamin E, beta-carotene and essential fatty acids.
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** Environmental stimulation
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** Drugs
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*** Selegiline
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*** Propentofylline
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*** Nicergoline
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[[Category:Central Nervous System - Degenerative Pathology]]
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