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T<sub>H</sub>1 cells secrete a range of cytokines, including:
 
T<sub>H</sub>1 cells secrete a range of cytokines, including:
* '''IL-2''', which induces proliferation of both [[Helper_CD4%2B#Helper_CD4.2B|CD4<sup>+</sup>]] and [[Cytotoxic_CD8%2B#Cytotoxic_CD8.2B|CD8<sup>+</sup> T-cells]]. This stimulation of T cell proliferation is the main function of the TH<sub>1</sub> cell.
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* '''IL-2''', which induces proliferation of both [[Helper_CD4%2B#Helper_CD4.2B|CD4<sup>+</sup>]] and [[Cytotoxic_CD8%2B#Cytotoxic_CD8.2B|CD8<sup>+</sup> T-cells]]. This stimulation of T cell proliferation is the main function of the T<sub>H</sub>1 cell.
 
* '''Interferon gamma''' ('''IFN&gamma;''') which activates tissue macrophages and is the principal effector mechanism in the defence against intracellular bacteria and parasites such as  Mycobacteria, Brucella, Rickettsia Leishmania, Coccidia, and Babesia. IFN&gamma; activates macrophages and stimulates them to produce enzymes triggering intracellular killing mechanisms - specifically:
 
* '''Interferon gamma''' ('''IFN&gamma;''') which activates tissue macrophages and is the principal effector mechanism in the defence against intracellular bacteria and parasites such as  Mycobacteria, Brucella, Rickettsia Leishmania, Coccidia, and Babesia. IFN&gamma; activates macrophages and stimulates them to produce enzymes triggering intracellular killing mechanisms - specifically:
 
#Superoxide dismutase and myeloperoxidase that produce H<sub>2</sub>O<sub>2</sub> and trigger the "superoxide burst".
 
#Superoxide dismutase and myeloperoxidase that produce H<sub>2</sub>O<sub>2</sub> and trigger the "superoxide burst".
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