Difference between revisions of "Testicular Feminisation"
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(New page: '''''Aetiology''''' * Genotype XY as should be in the male. * Testes develop normally and secrete Androgens and MIH * Foetal genetalia are genetically insensitive to the actions of Androg...) |
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| − | ''''' | + | <big><center>[[Reproductive System|'''BACK TO REPRODUCTIVE SYSTEM''']]</center></big> |
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| + | <big><center>[[Reproductive_System#Fertilisation.2C_Implantation_and_Early_Embryonic_Development|'''BACK TO FERTILISATION , IMPLANTATION and EARLY EMBRYONIC DEVELOPMENT''']]</center></big> | ||
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| + | <big><center>[[Fertilisation%2C_Implantation_and_Early_Embryonic_Development_-Sexual_Differentiation-_Anatomy_%26_Physiology#Associated_Disorders|'''BACK TO SEXUAL DIFFERENTIATION''']]</center></big> | ||
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| + | == Aetiology == | ||
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* Genotype XY as should be in the male. | * Genotype XY as should be in the male. | ||
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| + | == Consequence == | ||
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* Wolffian Ducts regress, allowing formation of '''female external genetalia''': | * Wolffian Ducts regress, allowing formation of '''female external genetalia''': | ||
** Labia | ** Labia | ||
Revision as of 11:16, 15 July 2008
Aetiology
- Genotype XY as should be in the male.
- Testes develop normally and secrete Androgens and MIH
- Foetal genetalia are genetically insensitive to the actions of Androgens due to a point mutation in the Androgen receptor.
Consequence
- Wolffian Ducts regress, allowing formation of female external genetalia:
- Labia
- Clitoris
- Vagina
- Sertoli cells are present and continue to secrete MIH, causing Mullarian Duct regression.
- Since both Wolffian AND Mullarian Ducts regress, there is no internal genetalia.