Difference between revisions of "Adrenogenital Syndrome"
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(New page: '''''Aetiology''''' * Genotype is XX as should be female * Ovaries develop normally * Foetal Adrenal Gland is hyperactive and secretes large quantities of Adrenal Androgens, due to a '''2...) |
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* Genotype is XX as should be female | * Genotype is XX as should be female | ||
* Ovaries develop normally | * Ovaries develop normally | ||
| − | * Foetal Adrenal Gland is hyperactive and secretes large quantities of Adrenal Androgens, due to a '''21 hydroxylase mutation'''. | + | * Foetal [[Endocrine_System_-_Adrenal_Glands_-_Anatomy_%26_Physiology|Adrenal Gland]] is hyperactive and secretes large quantities of Adrenal Androgens, due to a '''21 hydroxylase mutation'''. |
Revision as of 11:07, 3 July 2008
Aetiology
- Genotype is XX as should be female
- Ovaries develop normally
- Foetal Adrenal Gland is hyperactive and secretes large quantities of Adrenal Androgens, due to a 21 hydroxylase mutation.
Consequence
- Wolffian Ducts persist due to the presence of Androgens, thus allowing development of male internal and external genitalia.
- Mullarian Ducts persist due to the absence of testes, hence absence of Sertoli cell MIH secretion. This allows formation of female internal genitalia.
Morphology
- Appears male with a micropenis and scrotum
- Both male and female internal genitalia