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*The lens in the eye is often opaque due to deposition of sorbitol causing it to swell (glucose is converted into sorbitol once the glycolytic pathway is saturated)
 
*The lens in the eye is often opaque due to deposition of sorbitol causing it to swell (glucose is converted into sorbitol once the glycolytic pathway is saturated)
 
*In immune-mediated isletitis - progressive lymphoplasmacytic infiltration and selective destruction of islet cells
 
*In immune-mediated isletitis - progressive lymphoplasmacytic infiltration and selective destruction of islet cells
 +
*Possible vacuolation of islet cells and epithelium of small ducts
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