Materno-fetal Immunity Flashcards

MATERNO-FETAL IMMUNITY WIKIBLOOD FLASHCARDS

Passive Transfer and Failure of Passive Transfer (FPT)

Question	Answer	Article
How can antibodies be transferred between individuals?	Colostrum Crossing of the placenta Milk Vaccination Plasma transfusions	Link to Answer Article
Why do neonates require maternal antibodies?	Immunocompromised at birth due to a poorly developed immune system Mucosal surfaces are particularly vunerable Colostral and milk antibodies protect neonates from infection	Link to Answer Article
In which animals is there no passive transfer of IgG antibodies across the placenta?	Ruminants Horses Pigs	Link to Answer Article
What type of placenta do dogs and cats have?	Endotheliochorial	Link to Answer Article
What does colostrum contain?	Immune factors Growth factors Vitamins Minerals	Link to Answer Article
Which immunoglobulins are present in colostrum?	IgG in the largest amount IgA IgM	Link to Answer Article
True or False: IgA is most abundent in ruminant milk	False IgG is most abundent in ruminant milk IgA is most abundent in non-ruminant milk	Link to Answer Article
When does inadequate absorption of immunoglobulins occur in the neonate?	The neonate does not recieve colostrum The neonate does not recieve enough colostrum The neonate does not absorb enough colostrum The quality of the colostrum was inadequate	Link to Answer Article
What does colostrum quality depend upon?	Breed Nutrition Season Stress Immunostatus of the dam Milk yield Pre-milking Parity Dripping from the teats	Link to Answer Article
What does the quantity of colostrum depend upon?	Amount the neonate suckles Premature births	Link to Answer Article

Testing Colostrum Quality

Question	Answer	Article
True or False: Colostrum quality can not be determined by appearance	True	Link to Answer Article
How can colostrum be stored without reducing its immunological potential?	Freezing immediately will make the colostrum last for a year Refridgerating immediately will make the colostrum last for 5-7 days	Link to Answer Article
How can the immune status of colostrum be tested?	By a colostrometer Through using the Zinc Sulfate Turbidity (ZST) test Total serum protein can be calculated	Link to Answer Article
Which immunoglobulin levels does a colostrometer measure?	IgG	Link to Answer Article
Why must colostrum be tested by a colostrometer at room temperature (20°C)?	Above 20°C levels of IgG will be underestimated Below 20°C levels of IgG will be overestimated	Link to Answer Article
What levels of ZST units would indicate a healthy amount of passive transfer in calves?	Above 30 ZST units	Link to Answer Article
What levels of serum immunoglobulin would indicate a healthy amount of passive transfer in foals?	Above 800 mg/dl	Link to Answer Article
What is total serum protein levels measured by and at which ages should neonates be tested?	A refractometer 2-8 days old	Link to Answer Article
What levels of serum protein indicate the neonate is healthy and does not require further colostrum?	Above 4.5 mg/dl	Link to Answer Article

Neonatal Isoerytholysis (NI)

Question	Answer	Article
When does alloimmune haemalytic anaemia occur?	When a neonate inherits the sires blood type and drinks colostrum from the dam As the colostrum contains antibodies against the sire and thus the neonates red blood cells	Link to Answer Article
When does Neonatal Isoerytholysis occur?	First pregnancy from a stallion with incompatible blood type to the mare Subsequent pregnancy from the same stallion or same blood group as previously exposed to	Link to Answer Article

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