Difference between revisions of "Bovine Respiratory Syncytial Virus"
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====Pathogenesis==== | ====Pathogenesis==== | ||
*More serious than [[Bovine Parainfluenza - 3 (PI-3)|PI-3]] | *More serious than [[Bovine Parainfluenza - 3 (PI-3)|PI-3]] | ||
Revision as of 09:43, 27 March 2009
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This article is still under construction. |
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Pathogenesis
- More serious than PI-3
- Causes [Respiratory Viral Infections - Pathology#Respiratory syncytial virus|respiratory infection]]
- Replicates in nasal epithelium -> throughout upper respiratory tract -> bronchial tree
- Syncytia form -> shed into bronchioles
- Complications include emphysema and oedema, drop in milk yield in adult cattle
Epidemiology
- Subclinical reinfections are important in spreading disease
- More than 70% of cattle in the UK have antibodies to BRSV
Diagnosis
- Diseased lung tissue from dead animals or centrifuged cells from lung lavage
- Virus is too fragile for cell culture isolation (often inactivated in transport)
- Antigen detection by immunocytochemistry for intracytoplasmic viral inclusions containing labelled viral protein
- Serology: 4-fold rise in ELISA antibody in paired serum samples from several animals
Control
- Improve husbandry as in PI-3
- Vaccines are available but not effective as need to stimulate cytotoxic T-cells
Secondary Concerns
- Reference: Bryson, 1999, Update on calf pneumonia, CPD Veterinary Medicine, 1,3, 90-95