Difference between revisions of "Foot and Mouth Disease"
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(New page: {{unfinished}} {{toplink |linkpage =Viruses |linktext =VIRUSES |sublink1=Picornaviridae |subtext1=PICORNAVIRUSES |pagetype =Bugs }} <br> ====Morphology==== *Very small (25nm) RNA virus *...) |
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**3-7 days: ruptured vesicles, loss of epithelia, no marked fibrous margin | **3-7 days: ruptured vesicles, loss of epithelia, no marked fibrous margin | ||
**7-10+ days: open lesions with marked fibrous margin | **7-10+ days: open lesions with marked fibrous margin | ||
| − | * | + | *In the young, without maternal antibody, virus will localize in the heart and cause death by myocarditis |
| − | + | *FMDV causes '''loss of condition and productivity''' but is NOT typically fatal | |
| − | ***Lesion at '''coronary band''' means infection is usually less than a week old | + | |
| − | + | =====Pathogenesis by species===== | |
| − | + | *'''Pigs''' and '''Sheep''': | |
| − | *** | + | **Lesions less obvious, but vesicles around nose, mouth, and coronary band |
| + | **Lesion at '''coronary band''' means infection is usually less than a week old | ||
| + | **Lesions grow down claw at a rate of 1mm per week | ||
| + | *'''Cattle''' | ||
| + | **Lesions are seen inside mouth, around muzzle, in the interdigital cleft, around coronary band, and on teats | ||
| + | **Excessive salivation, anorexia, secondary mastitis | ||
| + | **PM: lesions in oesophagus and forestomachs | ||
| + | |||
====Epidemiology==== | ====Epidemiology==== | ||
Revision as of 19:04, 22 October 2008
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This article is still under construction. |
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Morphology
- Very small (25nm) RNA virus
- 12 capsomeres (1 per vertex)
- 5 subunits per capsomere
- 1 molecule of virus protein (VP) per subunit
- 4 virus proteins (VP1-VP4)
- VP1 is the attachment protein
Antigenicity
- FMDV was the first animal virus in which serotypes were isolated
- To date, there are (important in bold):
- Oise (O)
- Allemagne (A)
- C (also German)
- South African Territories (SAT) 1, 2, and 3
- India (Asia-1)
- Each serotype has at lease three subtypes
- Serotype and subtype can be quickly identified by ELISA using guinea pig antisera
- All isolates are virulent
Hosts
- Cloven-hoofed animals, EXCLUDING the horse
- Cattle
- Sheep
- Goats
- Pigs
- Deer
- Elephants
- Wild ruminants: buffalo, kudu, impala, etc
Pathogenesis
- Primary replication in the upper respiratory tract, tonsils, or upper alimentary tract
- Aerosol excretion during this incubation period
- Viremia
- Virus targets stratum spinosum of stratified squamous epithelia and mucus mebranes
- Secondary vesicles appear after incubation of 2-14 days
- Appearance of lesions by age:
- 0-2 days: unruptured vesicles
- 1-3 days: newly ruptured vesicles with adherent epithelia at margins
- 3-7 days: ruptured vesicles, loss of epithelia, no marked fibrous margin
- 7-10+ days: open lesions with marked fibrous margin
- In the young, without maternal antibody, virus will localize in the heart and cause death by myocarditis
- FMDV causes loss of condition and productivity but is NOT typically fatal
Pathogenesis by species
- Pigs and Sheep:
- Lesions less obvious, but vesicles around nose, mouth, and coronary band
- Lesion at coronary band means infection is usually less than a week old
- Lesions grow down claw at a rate of 1mm per week
- Cattle
- Lesions are seen inside mouth, around muzzle, in the interdigital cleft, around coronary band, and on teats
- Excessive salivation, anorexia, secondary mastitis
- PM: lesions in oesophagus and forestomachs