Difference between revisions of "Levamisole"
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| + | * Levamisole belongs to the imidazothiazoles class of drugs. | ||
* This is one of the most widely used anthelmintics and can be given orally, by injection or as a pour on. | * This is one of the most widely used anthelmintics and can be given orally, by injection or as a pour on. | ||
* It is active against adult '''[[Nematodes]]''', but has limited action against the larval stages, especially the hypobiotic phase. | * It is active against adult '''[[Nematodes]]''', but has limited action against the larval stages, especially the hypobiotic phase. | ||
* It is a cholinergic agonist at neural and neuromuscular junctions causing a '''spastic paralysis''' of the nematode. The nematodes succumb rapidly to it. | * It is a cholinergic agonist at neural and neuromuscular junctions causing a '''spastic paralysis''' of the nematode. The nematodes succumb rapidly to it. | ||
* It is rapidly absorbed and excreted and its potency is related to its peak plasma concentrations. Therefore pour-on products need a higher dose, as they are absorbed more slowly, to reach the same plasma concentrations. | * It is rapidly absorbed and excreted and its potency is related to its peak plasma concentrations. Therefore pour-on products need a higher dose, as they are absorbed more slowly, to reach the same plasma concentrations. | ||
Latest revision as of 21:39, 29 September 2009
- Levamisole belongs to the imidazothiazoles class of drugs.
- This is one of the most widely used anthelmintics and can be given orally, by injection or as a pour on.
- It is active against adult Nematodes, but has limited action against the larval stages, especially the hypobiotic phase.
- It is a cholinergic agonist at neural and neuromuscular junctions causing a spastic paralysis of the nematode. The nematodes succumb rapidly to it.
- It is rapidly absorbed and excreted and its potency is related to its peak plasma concentrations. Therefore pour-on products need a higher dose, as they are absorbed more slowly, to reach the same plasma concentrations.