Difference between revisions of "Category:Endocardial Pathology"

Functional Anatomy

The endocardium is a smooth layer continuous with the lining of the blood vessels. The endocardium also provides the structure to the valve leaflets. Because of its close association with the blood, endocardium is particularly at risk of trauma and haematogenous infection.

Valvular disease is very rare in the cat, further discussion refers to canine disease.

Category:Cardiovascular System - Degenerative Pathology

Valvular Endocardiosis

Endocardial Mineralisation

Chronic Valvulitis

Seen in the horse. Lesions are fibrous with sparse chronic inlammatory cells and scarring. Most significant lesions affect the mitral and tricuspid valves.

Inflammatory-Endocarditis

Usually due to bacterial infection. More common in cattle, pigs and sheep. Often due to a chronic bacteraemia or pyaemia, spread from adjacent myocardium is rare.

Organisms commonly isolated include:

• Cattle: Actinomyces pyogenes
• Pigs: Erysipelothrix spp.
• Sheep: Streptococci.

Pathogenesis:

Contributing factors include:

• Trauma: haemodynamic turbulence.
• Valve tissue ageing.
• Avascularity of valves; poor healing capacity.
• Tissue exposure; constant contact with blood-borne pathogens.

Vegetative endocarditis

Predisposed by valvular damage as thrombi occur on the surface of the valves exposed to blood flow. Needs sustained or recurrent bacteraemia. Some bacteria have particular adherence properties and may only need a single episode of bacteraemia to set up an endocarditis.

Pathophysiology:

Loose thrombi of platelets and fibrin form which build up to larger vegetations. Bacterial colonies are found within the mass. Attempts to organise the vegetation occur but complete healing very rarely occurs. The mass may become ulcerated. Progression to rupure of the chordae tendinae is possible, along with spread of the infection to the adjacent mural endocardium. Valves may become stenotic, incompetant or both.

Death usually results from either embolisation of the vegetation or congestive heart failure due to significant valvular damage.

Species differences:

• Cattle: predominantly affects the tricuspid valve, perhaps due to bacteria arising in the GI tract and liver. Congestive right sided failure is manifested as ascites (including bottle jaw) and embolisation to the lungs. Anaemia is often present as the red blood cells are damaged as they pass through the vegetation.
• Pig and dog: Lesions occur particularly on the mitral valve, perhaps due to the higher pressure blood flow on the left side of the heart leading to more valvular damage. Left sided heart failure and pulmonary oedema are seen clinically, as are emboli in various organs, particularly the kidney.

Ulcerative endocarditis

Commonly seen along with renal failure in dogs. Uraemia irritates and damages the endocarium, particularly in the left atrium. Oedema is seen in the sunendocardial tissue with deposition of glycosaminoglycans.

Healing may occur by fibrosis or the lesion may progress to a necrotising endcarditis and, in extreme cases, left atrial rupture. If renal sufficieny is re-established then healing of the endocardial lesion is possible.

Vascular Pathology

Haemorrhage

Seen as an incidental finding in horses and catte due to sudden death.

Atrial thrombosis

Atrial dilation or fibrillation on dogs and cats allows abnormal eddying and stasis of blood within the atria. Thrombosis may occur with subsequent embolisation of thrombus and lodging in smaller vessels. This particularly occurs in the cat where thrombi lodge in the femoral artery. The platelets within the thrombus release vasoactive amines which potentiate the hypoxia by constricting collateral circulation to the hindlimb. The cat will present with an acute hind limb paralysis with the limbs affected being cold to the touch and without a femoral pulse.

Embolism elsewhere is usually clinically silent.

Blood cysts

Haematoma formation within the AV-valve leaflets.

Proliferative Pathology

Haemangioendothelioma

Arise from the endothelial cells, usually of the right atrium and occasionally involving the right ventricle.

Often multiple with similar tumours in the spleen.

Chemodectoma

Tumour arising from the chemoreceptor cells of the aortic body. Usually benign although local enlargement causes clinical signs early on E.g. dyspnoea.

The heart is also a site of secondary neoplasia, particularly mammary and thyroid adenocarcinomas and haemangiosarcomas.