Difference between revisions of "Dichelobacter nodosus"
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**Antibody must penetrate the epidermal layers and reach adequate concentration on the skin surface | **Antibody must penetrate the epidermal layers and reach adequate concentration on the skin surface | ||
**Vaccine available | **Vaccine available | ||
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| + | [[Contagious Footrot]] | ||
[[Category:Pathogenic_anaerobic_non-spore-forming_Gram-negative]][[Category:Sheep]] | [[Category:Pathogenic_anaerobic_non-spore-forming_Gram-negative]][[Category:Sheep]] | ||
[[Category:To_Do_-_Bacteria]] | [[Category:To_Do_-_Bacteria]] | ||
Revision as of 11:16, 30 June 2010
- Formerly known as Bacteroides
- Characteristics:
- Large Gram negative rods with terminal swellings
- Long polar fimbriae
- 16 antigenic types of fimbriae - used to differentiate strains antigenically
- All strains possess same O antigen
- Colonies of virulent strains have a dark central zone, a pale granular middle zone and an irregular periphery
- Strains detected by ELISA and PCR
- Thermostable proteases and elastase contribute to pathogenesis
- Keratinolytic proteases required for virulence
- Fimbriae required for adhesion to hoof
- Primary pathogen of epidermal tissues of hoof of ruminants, suriving briefly in the envionment
- Passed from animal to animal
- Causes foot rot in sheep along with other bacteria
- Ovine footrot:
- Contagious, economically important disease
- Wet pasture and hydrated stratum corneum leads to colonisation by Gram positive cocci and Arcanobacter pyogenes, followed by F. necrophorum; addition of D. nodosus causes footrot
- Can lead to loss of hoof
- Immunity:
- Homologous antibody to fimbrial antigen prevents adhesion and protects against footrot
- Antibody must penetrate the epidermal layers and reach adequate concentration on the skin surface
- Vaccine available