Uraemia

Lesions due to uraemia associated with pyelonephritis/chronic renal failure (Courtesy of Alun Williams (RVC))

• In terminal renal failure animal may present with painful ulcers in mouth, which become secondarily infected with Fusiformis.
  • High concentrations of toxic materials in the blood results in degeneration of small arterioles.
• In the mouth, this damage to the blood supply can cause epithelial necrosis.
• Usually seen as erosions along the ventrolateral borders of the tongue and on the cheeks, especially opposite the teeth.
• In some cases there may be more extensive necrosis which may involve subepithelial tissue
  • for example, the tip of the tongue may slough.
• Most commonly seen in dog sometimes in cat.