Difference between revisions of "Respiratory Bacterial Infections - Pathology"

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===Melioidosis (Pseudoglanders)===
+
===[[Melioidosis]] ===
 
 
*Caused by [[:Category:Pseudomonas and Burkholderia species|''Pseudomonas (Malleomyces) pseudomallei'']], Closely related to [[Burkholderia mallei|''P. mallei'']] in [[Hindgut Fermenters - Horse - Anatomy & Physiology|horses]]
 
*Causes disease in sheep, goats and pigs, occasionally other species
 
*Starts as a pyemia and localises in varius tissues, including the lung as abscessation
 
**Encapsulated abscesses contain yellow, caseous or creamy pus
 
*[[Lungs Inflammatory - Pathology#Infectious causes of pneumonia|Pneumonia]] and arthritis are the most common presentation
 
  
 
==In Pigs==
 
==In Pigs==

Revision as of 14:13, 30 June 2010


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()Map CARDIORESPIRATORY SYSTEM (Map)
RESPIRATORY SYSTEM INFLAMMATION



In general

  • Main clinical expression is as secondary invaders of previously damaged lung tissue due to viral or parasitic involvement or environmental stress
  • Some are initial pathogens in their own right while others can damage the tract allowing invasion by more pathogenic types

In Dogs

Infectious Canine Tracheitis

Tuberculosis - Dogs

Nocardiosis

In Cats

Chlamydiosis, Feline

Mycoplasma felis

In Horses

Strangles

Streptococcus equi subsp. zooepidemicus

Glanders

Rhodococcus equi

In Cattle

Necrotic Laryngitis

Cillia-associated Respiratory Bacillus

Pneumonic Pasteurellosis

Tuberculosis - Cattle

Contagious Bovine Pleuropneumonia

Enzootic Pneumonia - Calves

Acute Exudative Pneumonia

In Sheep

Laryngeal Chondritis

CAR bacillus

Enzootic Pneumonia - Lambs

Melioidosis

In Pigs

Atrophic Rhinitis

Severe atrophic rhinitis (Image sourced from Bristol Biomed Image Archive with permission)
  • Atrophy of nasal turbinates and distortion and shortening of the snout
  • Caused by co-infection of the nasal mucosa with
    • Bordetella bronchiseptica
      • Appears to facilitate colonisation of nasal epithelium by the toxigenic Pasteurella
    • Toxin-producing strain of Pasteurella multocida capsular type D (or sometimes A)
      • Experimental evidence shows that the toxin acts directly on bone cells of the nasal turbinates to cause bone loss, each pathogen can cause atrophy itself but greater damage when together
  • Exacerbated by adverse dietary and managemental factors
  • In rapidly growing young pigs (4-12 weeks old)
  • Clinical signs
    • Progressive facial deformity with rhinitis, catarrhal nasal discharge
    • Sneezing, coughing, can progress to dyspnoea and anorexia
  • Gross pathology
    • Overlying skin on shortened snout is thrown into folds
    • Deviation of the snout to most affected side
    • Various loss of turbinate bone, ventral usually more affected
    • Deviation of nasal septum away from affected chamber
    • Inflammatory, haemorrhagic and ulcerative lesions in the nasal mucosa
  • Micro pathology
    • Reduction in the amount of bone in the turbinates
    • No osteoid laid down between osteoblasts and existing bone
    • Increased fibrous tissue
    • Non-specific mucosal inflammation
  • 2 forms of the disease
    • 'Progressive' atrophic rhinitis
      • Due to infection of the nasal turbinates by P.multocida strains carrying the toxA gene that encodes for an osteolytic toxin. P.multocida adheres poorly to mucous membranes, and therefore requires a predisposing nasal insult to assist colonisation eg: co-infection with B.bronchiseptica or Porcine cytomegalovirus (inclusion body rhinitis)
      • Turbinate bone atrophy is permanent and progressive
    • 'Non-progressive' atrophic rhinitis
      • Due to infection of the nasal turbinates by Bordetella bronchiseptica strains alone, that carry a gene that encodes for a dermonecrotic toxin.
      • Turbinate bone can regenerate by the time of slaughter

Necrotic laryngitis in pigs

Enzootic pneumonia of pigs

Enzootic pneumonia of pigs(Image sourced from Bristol Biomed Image Archive with permission)
  • Caused by Mycoplasma hyopneumoniae and Mycoplasma hyorhinis
  • Also called mycoplasmal pneumonia
  • Major cause of unthriftiness in young pigs
  • Pneumonia in weaned pigs
  • Cough, reduced growth rate
  • Attached to cilia - no mucociliary clearance
  • Usually non-fatal unless there is secondary infection (e.g. Pasteurella multocida)
  • Gross pathology:
    • Confluent consolidation of the cranioventral lung lobes
    • In other areas there may be small red to grey focal lesions evident which indicate the bronchiolar orientation of the inflammatory process
  • Histologically
    • Changes result from a catarrhal bronchointerstitial pneumonia
    • In chronic cases, prominent accumulations of lymphoid cells can be seen around airways and blood vessels

Actinobacillus pleuropneumoniae

Pasteurellosis in pigs

Contagious porcine pleuropneumonia

  • Caused by Haemophilus (Actinobacillus) pleuropneumonia
  • Seen mainly between 6wks-6mths of age but will affect any age
  • Highly pathogenic strains are capable of initiating disease on their own with high mortality in young pigs
  • A fibrinonecrotic bronchopneumonia with pleurisy
  • Foci of haemorrhagic consolidation or necrosis, mainly around major bronchi, tend to sequestrate
  • Tending to spread throughout all lung lobes: therefore a cranioventral distribution may not be particularly evident

Glasser's disease

Streptococcal pneumonia

Tuberculosis in pigs

  • Pigs are susceptible to the Mycobacterium spp. causing tuberculosis in cattle
  • Rarely extends to lungs after haematogenous spread from ingested bacteria causing tubercles with various degrees of calcification, encapsulation and caseation

In Rabbits

Snuffles

CAR bacillus