Fasciola hepatica

Also known as:

Liver Fluke

Fasciola Hepatica is an hepatic parasite found in mainly in ruminants, namely cows, sheep and goats, but also known to affect horses and pigs. It is commonly found within the UK, with its prevalence ever increasing. It is responsible for a 10-15% production loss in each infected animal, as it affects meat, milk and wool production, so is of huge economic consequence.

Fasiola Hepatica has a definitive ruminant mammalian host and an intermediate molluscian host. The full life cycle is illustrated in the image aside.

Scientific Classification

Kingdom	Animalia
Phylum	Platyhelminthes
Class	Trematoda
Subclass	Digenea
Order	Echinostomida
Family	Fasciolidae
Genus	Fasciola
Species	F. Hepatica

• can cause severe haemorrhagic liver damage
• death in heavy infestations in sheep during migratory phase (1 month) through the liver tissue
• recovered animals will have scarred livers
• more commonly associated with chronic bile duct inflammation - cholangitis [need link to below]
  • the adults live in the bile ducts

Fasciola hepatica (Copyright Adam Cuerden, Wikimedia Commons)

Pathogenesis

The severity of the infection is mainly dependent on the number of metacercariae ingested. The Pathogenesis is often described as two-fold. The first stage occuring when the parasite migrates through the liver parenchyma, causing liver damage and haemorrhage. The second phase occurs when the parasite is in the bile ducts, and damage is a result of the haematophagic activity of the adult flukes.

Acute Fascioliasis

The acute disease is a less common type of Fasciola hepatica, and generally occurs 2-6 weeks after large ingestion of metacercariae. The young liver flukes migrate through the liver parenchyma causing severe haemorrhaging, due to the damage to the liver vasculature. Acute disease associated with immature fluke migration through the liver This occurs in late autumn and winter, mainly between the months of August to October.

• severity of outbreaks depend on a number of epidemiological factors
• the liver of animals which die of this disease will be
  • enlarged
  • haemorrhagic
  • honeycombed with the tracts of migrating flukes
    • tracts become filled with blood and degenerate hepatocytes later infiltrated with eosinophils, lymphocytes and replaced by fibrosis
  • surface is covered with a fibrinous peritonitis, especially the ventral lobe
  • subcapsular haemorrhages are frequent
  • rupture into the abdomen is not an uncommon finding

File:Fasciola hepatica - life cycle.jpg

Fasciola hepatica life cycle(Copyright Centres for Disease Control and Prevention)

Chronic Fascioliasis

Gross

• liver is reduced in size, unevenly
  • left lobe is most severely affected with atrophy of the extremities
• hypertrophy may occur in some cases
  • dorsal lobe
  • this changes size and distorts shape of liver
• the surface will be uneven with areas of fibrous tissue replacing the cells damaged by the migrating flukes
• bile ducts
  • prominent thick protruding white bile ducts on the visceral surface spreading from the hilus to the left lobe
  • the bile ducts are dilated, black, and calcified on cut surface
  • numerous adult flukes can be expressed from the bile ducts
  • chronic cholangitis
  • 'pipe stem' appearance in cattle because bile ducts are very much thickened and often calcified
• bile
  • dark brown, thick, and gritty in consistency

NB: the fibrosis which occurs in the chronic stage is realted only partly to the healing of the migratory tracts and the rest may be related to the development of immunity and rechallenge

Microscopically

• reactive hyperplasia of the bile ducts
• substantial inflammatory cell infiltrate and peripheral fibrosis
• calcification of the chronically damaged tissue