Difference between revisions of "Gastrinoma"
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| + | {|cellpadding="10" cellspacing="0" border="1" | ||
| + | | Also known as: | ||
| + | | '''Zollinger-Ellison Syndrome''' | ||
| + | |} | ||
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| + | ==Description== | ||
| + | A gastrinoma is a neoplasm of pancreatic islet cells that secretes the hormone gastrin, an example of a ectopic paraneoplastic disease. The disease was first described by Zollinger and Ellison in humans in 1955 and it has since been recognised occasionally in dogs and cats. | ||
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| + | The excessive secretion of gastrin leads to hyperstimulation of gastric acid production from the parietal cells of the stomach. | ||
[http://w3.vet.cornell.edu/nst/nst.asp?Fun=Image&imgID=7762 Image of pancreatic garstrinoma in a dog from Cornell Veterinary Medicine] | [http://w3.vet.cornell.edu/nst/nst.asp?Fun=Image&imgID=7762 Image of pancreatic garstrinoma in a dog from Cornell Veterinary Medicine] | ||
*Described in dogs, cats | *Described in dogs, cats | ||
Revision as of 16:52, 23 July 2010
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This article is still under construction. |
| Also known as: | Zollinger-Ellison Syndrome |
Description
A gastrinoma is a neoplasm of pancreatic islet cells that secretes the hormone gastrin, an example of a ectopic paraneoplastic disease. The disease was first described by Zollinger and Ellison in humans in 1955 and it has since been recognised occasionally in dogs and cats.
The excessive secretion of gastrin leads to hyperstimulation of gastric acid production from the parietal cells of the stomach. Image of pancreatic garstrinoma in a dog from Cornell Veterinary Medicine
- Described in dogs, cats
- Known as Zollinger-Ellison syndrome in humans
- Uncommon compared to beta cell neoplasms
- Excess gastrin causes hyperacidity in the stomach and mucosal hyperplasia of the antral region causing gastric and duodenal ulceration
Clinical signs
Pathology
- Multiple variably sized neoplasms
- Increased connective tissue mass - firm
- Partiallty encapsulated
- Invade locally
- Metastases to liver and local lymph nodes are common