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| | Simple serology is impossible as most cats will have antibody to FECoV. | | Simple serology is impossible as most cats will have antibody to FECoV. |
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| − | However, 4 indicators can be used to cross reference: | + | However, 4 indicators can be used for diagnosis: |
| − | *High FECoV Ab titres | + | *High FECoV Antibody titres |
| | *Low albumin:globulin ratio in plasma/ascites (globulin levels rise in FIP) | | *Low albumin:globulin ratio in plasma/ascites (globulin levels rise in FIP) |
| | *High levels of glycoprotein alpha 1-acid glycoprotein (AGP) | | *High levels of glycoprotein alpha 1-acid glycoprotein (AGP) |
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| | Uveitis, hydrocephalus, neurological symptoms, such as ataxia or seizures and chronic diarrhoea. | | Uveitis, hydrocephalus, neurological symptoms, such as ataxia or seizures and chronic diarrhoea. |
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| − | ====Epidemiology====
| + | |
| − | *FECoV is '''endemic worldwide''', with the majority of cats showing a subclinical seroconversion
| |
| − | *'''Orofecal, aerosol, and contact''' transmission
| |
| − | *Particular concern for '''catteries''' and homes with '''multiple cats'''
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| − | *
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| | ==Pathology== | | ==Pathology== |
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| | ==Control== | | ==Control== |
| − | Conventional vaccination is counterproductive as antibody worsens infection however a non-systemic vaccine (Primucell) is available outside the UK | + | Conventional vaccination is counterproductive as antibody worsens infection however a non-systemic vaccine (Primucell) is available outside the UK. Replication confined to nasal mucosa, providing local immunity and cell-mediated immunity and it cannot protect cats already infected with FECoV. |
| − | **Temperature-sensitive mutant
| + | Antibody tests are available to certify FECoV-free cat houses. |
| − | **Replication confined to nasal mucosa, providing local immunity and cell-mediated immunity
| |
| − | **Cannot protect cats already infected with FECoV
| |
| − | **Kittens must be isolated until old enough to vaccinate at 16 weeks
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| − | Antibody tests are available to certify "FECoV-free" cat houses | |
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