Difference between revisions of "Neutrophilia"
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(Created page with "* Neutrophilia is an increase in the number of neutrophils in the blood. * Neutrophilia is often accompanied by the release of substantial numbers of immature neutrophils into th...") |
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| − | * Neutrophilia is an increase in the number of neutrophils in the blood. | + | {{unfinished}} |
| + | ==Introduction== | ||
| + | * Neutrophilia is an increase in the number of [[Neutrophil|neutrophils]] in the blood. | ||
* Neutrophilia is often accompanied by the release of substantial numbers of immature neutrophils into the blood stream. | * Neutrophilia is often accompanied by the release of substantial numbers of immature neutrophils into the blood stream. | ||
** Do not have segmented nuclei. | ** Do not have segmented nuclei. | ||
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** When the percentage of these immature forms is high, it is referred to as a "left shift". | ** When the percentage of these immature forms is high, it is referred to as a "left shift". | ||
| − | + | ==Causes of Neutrophilia== | |
Purulent Foci: | Purulent Foci: | ||
* Purulent foci and abscesses in the body produce substantial neutrophilia. | * Purulent foci and abscesses in the body produce substantial neutrophilia. | ||
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| − | [[Category:Inflammation]] | + | [[Category:Inflammation]][[Category:To Do - Blood]] |
Revision as of 10:41, 4 August 2010
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This article is still under construction. |
Introduction
- Neutrophilia is an increase in the number of neutrophils in the blood.
- Neutrophilia is often accompanied by the release of substantial numbers of immature neutrophils into the blood stream.
- Do not have segmented nuclei.
- Nuclei appear as elongated bent tubes in the cytoplasm .
- Are called "band cells".
- The presence of band cells in the blood represent an intense need for neutrophils due to them being lost in the purulence.
- When the percentage of these immature forms is high, it is referred to as a "left shift".
- Do not have segmented nuclei.
Causes of Neutrophilia
Purulent Foci:
- Purulent foci and abscesses in the body produce substantial neutrophilia.
- For example, neutrophilia is produced in
- Pyometra
- Pus in the uterus.
- Empyema
- Pus in a body cavity
- E.g. Nocardia infection in the thoracic cavity.
- Pus in a body cavity
- Pyometra
- In very severe infections, such at those above, the neutrophil granules become more apparent in the cytoplasm and stain bluish, and some cytoplasmic vacuolation may be seen.
- These 'toxic' neutrophils have decreased bactericidal capability and do not respond as quickly to chemotactic stimuli.
Bacteria
- Bacteria,particularly pyogenic forms, cause neutrophilia.
Necrosis
- Necrosis of any kind will result in neutrophilia.
- Necrosis from burns, malignancies and infection are particularly involved.
Fungi
- For example, aspergillosis.
Viruses
- Neutrophils may be present, but are not the main component of inflammaory cells.
- Examples:
Parasites
- Neutrophils may be present, but are not the main componentof inflammatory cells.
- Examples
Immune-Mediated Conditions
- Neutrophils may be present, but are not the main component of inflammatory cells.
- Examples:
- Rheumatoid arthritis
- Systemic Lupus Erythematosus
- Autoimmune Haemolytic Anaemia
Other Factors
- Other factors which will produce a neutrophilia are:
- Excitement, fear, and strenuous exercise in young animals.
- Corticosteroids; either :
- Released endogenously in pain or thermal stress, or
- Exogenous therapeutic administration.
- Neutrophilia oocures 4-8 hours post administration of the corticosteroid drug.