Difference between revisions of "Gastric Squamous Cell Carcinoma - Horse"
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==Clinical Signs and Diagnosis== | ==Clinical Signs and Diagnosis== | ||
| − | The main clinical signs include '''weight loss''' and general ill health.<ref name="Merck">Merck & Co (2008) '''The Merck Veterinary Manual (Eighth Edition)''', ''Merial''.</ref> Other signs may include anorexia, abdominal distension, and abnormal chewing and swallowing behaviour.<ref name="Olsen2">Olsen, S.N (1992) Squamous-cell carcinoma of the equine stomach: a report of 5 cases. ''Vet Rec'', 131:170-173.</ref> '''Hypertrophic osteopathy''' associated with this neoplastic disease has been reported in one horse.<ref>Schleining, J.A, Voss, E.D (2004) Hypertophic osteopathy secondary to gastric squamous cell carcinoma in a horse. ''Equine Vet Educ'', 16:304-307. In: Zimmel, D.N (2010) ''Neoplasia of the Alimentary Tract'' in Reed, S.M, Bayly, W.M. and Sellon, D.C (2010) '''Equine Internal Medicine''' (Third Edition), ''Saunders'', Chapter 15.</ref> Diagnosis is made by exclusion of other causes of weight loss and gastroscopy. Haematology may reveal a normocytic anaemia, neutrophilia and hypoalbuminaemia.<ref name="Olsen2">Olsen, S.N (1992) Squamous-cell carcinoma of the equine stomach: a report of 5 cases. ''Vet Rec'', 131:170-173.</ref> [[Colic Diagnosis - Abdominocentesis|Abdominocentesis]] may demonstrate abnormal peritoneal effusions with neoplastic cells. Nodules lining the peritoneum may be seen at ''post-mortem'' examination.<ref name="Olsen2">Olsen, S.N (1992) Squamous-cell carcinoma of the equine stomach: a report of 5 cases. ''Vet Rec'', 131:170-173.</ref> | + | The main clinical signs include '''weight loss''' and general ill health.<ref name="Merck">Merck & Co (2008) '''The Merck Veterinary Manual (Eighth Edition)''', ''Merial''.</ref> Other signs may include anorexia, lethargy, abdominal distension, hypersalivation, pyrexia, tachypnoea, reduced borborygmi<ref name="Talor">Taylor S.D, Haldorson, G.J, Vaughan, B, Pusterla, N (2009) Gastric neoplasia in horses. ''J Vet Intern Med'', 23(5):1097-102.</ref> and abnormal chewing and swallowing behaviour.<ref name="Olsen2">Olsen, S.N (1992) Squamous-cell carcinoma of the equine stomach: a report of 5 cases. ''Vet Rec'', 131:170-173.</ref> '''Hypertrophic osteopathy''' associated with this neoplastic disease has been reported in one horse.<ref>Schleining, J.A, Voss, E.D (2004) Hypertophic osteopathy secondary to gastric squamous cell carcinoma in a horse. ''Equine Vet Educ'', 16:304-307. In: Zimmel, D.N (2010) ''Neoplasia of the Alimentary Tract'' in Reed, S.M, Bayly, W.M. and Sellon, D.C (2010) '''Equine Internal Medicine''' (Third Edition), ''Saunders'', Chapter 15.</ref> Diagnosis is made by exclusion of other causes of weight loss and gastroscopy. Haematology may reveal a normocytic anaemia, neutrophilia and hypoalbuminaemia.<ref name="Olsen2">Olsen, S.N (1992) Squamous-cell carcinoma of the equine stomach: a report of 5 cases. ''Vet Rec'', 131:170-173.</ref> [[Colic Diagnosis - Abdominocentesis|Abdominocentesis]] may demonstrate abnormal peritoneal effusions with neoplastic cells. Nodules lining the peritoneum may be seen at ''post-mortem'' examination.<ref name="Olsen2">Olsen, S.N (1992) Squamous-cell carcinoma of the equine stomach: a report of 5 cases. ''Vet Rec'', 131:170-173.</ref> |
==Treatment and Prognosis== | ==Treatment and Prognosis== | ||
Revision as of 19:08, 10 August 2010
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This article is still under construction. |
| Also known as: | Gastric Neoplasia |
| See also: | Colic, Gastric Causes |
Description
Squamous cell carcinoma is the most common tumor of the equine stomach.[1] It can affect the cardia and upper squamous regions of the stomach, resulting in a persistent mild colic, commonly seen soon after feeding. The tumor can invade and metastasize to lymph nodes, the lungs and regions palpable on rectal examination.[1]
Clinical Signs and Diagnosis
The main clinical signs include weight loss and general ill health.[2] Other signs may include anorexia, lethargy, abdominal distension, hypersalivation, pyrexia, tachypnoea, reduced borborygmi[3] and abnormal chewing and swallowing behaviour.[4] Hypertrophic osteopathy associated with this neoplastic disease has been reported in one horse.[5] Diagnosis is made by exclusion of other causes of weight loss and gastroscopy. Haematology may reveal a normocytic anaemia, neutrophilia and hypoalbuminaemia.[4] Abdominocentesis may demonstrate abnormal peritoneal effusions with neoplastic cells. Nodules lining the peritoneum may be seen at post-mortem examination.[4]
Treatment and Prognosis
In most cases, surgical resection is not possible[6] and the prognosis is grave.
References
- ↑ 1.0 1.1 Olsen, S.N (1992) Squamous-cell carcinoma of the equine stomach: a report of 5 cases. Vet Rec, 131:170-173. In: Zimmel, D.N (2010) Neoplasia of the Alimentary Tract in Reed, S.M, Bayly, W.M. and Sellon, D.C (2010) Equine Internal Medicine (Third Edition), Saunders, Chapter 15.
- ↑ Merck & Co (2008) The Merck Veterinary Manual (Eighth Edition), Merial.
- ↑ Taylor S.D, Haldorson, G.J, Vaughan, B, Pusterla, N (2009) Gastric neoplasia in horses. J Vet Intern Med, 23(5):1097-102.
- ↑ 4.0 4.1 4.2 Olsen, S.N (1992) Squamous-cell carcinoma of the equine stomach: a report of 5 cases. Vet Rec, 131:170-173.
- ↑ Schleining, J.A, Voss, E.D (2004) Hypertophic osteopathy secondary to gastric squamous cell carcinoma in a horse. Equine Vet Educ, 16:304-307. In: Zimmel, D.N (2010) Neoplasia of the Alimentary Tract in Reed, S.M, Bayly, W.M. and Sellon, D.C (2010) Equine Internal Medicine (Third Edition), Saunders, Chapter 15.
- ↑ East, L.M, Savage, C.J (1998) Abdominal neoplasia (excluding urogenital tract). Vet Clin North Am Equine Pract, 14:475-493. In: Zimmel, D.N (2010) Neoplasia of the Alimentary Tract in Reed, S.M, Bayly, W.M. and Sellon, D.C (2010) Equine Internal Medicine (Third Edition), Saunders, Chapter 15.