Difference between revisions of "Diffuse Fibrosing Alveolitis"
Jump to navigation
Jump to search
(Created page with "Diffuse Fibrosing Alveolitis/ Interstitial Pneumonia *Diffuse inflammatory process which occurs distal to the terminal bronchioles *Characterised by thickening and fibrosis of t...") |
m (Text replace - "Category:To Do - Blood" to "Category:To Do - BloodCategory:To Do - Clinical") |
||
| Line 10: | Line 10: | ||
| − | [[Category:Allergic Respiratory Diseases]][[Category:To Do - Blood]] | + | [[Category:Allergic Respiratory Diseases]][[Category:To Do - Blood]][[Category:To Do - Clinical]] |
Revision as of 10:54, 20 August 2010
Diffuse Fibrosing Alveolitis/ Interstitial Pneumonia
- Diffuse inflammatory process which occurs distal to the terminal bronchioles
- Characterised by thickening and fibrosis of the alveolar walls
- The precise underlying aetiology of this condition is obscure and it is likely to represent the end stage of a variety of initial insults including EAA and fog fever
- Progression from an acute exudative phase through a proliferative phase (proliferation of type II pneumocytes) to a final irreversible stage of fibrosis is the hallmark of DFA
- The rate of the ensuing fibrosis is heavily dependant on the intensity of the inflammation associated with it
- Underlying pathogenesis of the fibrosis is complex and involves a relative increase of type I collagen fibres (dense, high tensile strength) over type III fibres (reticulin)
- Stimulation of fibroblast proliferation and collagen deposition are thought to be induced by macrophage derived cytokines, e.g. IL-1, TGFalpha and TGFbeta, GM-CSF