Difference between revisions of "Canine Cyclic Haematopoiesis"
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(Created page with "thumb|right|150px|Appearance of a puppy with Grey Collie syndrome - Copyright Michelle Tennis & Peggy Melton *Also called '''Grey Collie Syndro...") |
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Revision as of 13:47, 12 August 2010
- Also called Grey Collie Syndrome
- Autosomal recessive
- Insertion mutation in AP3B1 gene
- Diluted grey coat colour, stunted growth, poor wound healing
- Neutropenia every 2 weeks which lasts 3-4 days due to cyclic production of cells from bone marrow
- Animals are prone to recurrent infections, mainly from the respiratory and gastrointestinal tract
- E.g. pyrexia, diarrhoea, gingivitis and arthritis
- Puppies can be distinguished from other litter mates by the diluted grey colouring
- Affected puppies show symptoms such as fever, joint pain and eye, skin and respiratory infections from 8 weeks of age
- Affected animals rarely live beyond 2-3 years with most puppies dying within a few weeks of birth