Changes

When secondary haemostasis is abnormal, larger bleeds are frequently seen. Haemothroax, haemoperitoneum, or haemoarthrosis may occur, in addition to subcutaneous and intramuscular haemorrhages. Petechia and ecchymoses are not usually apparent, as intact primary haemostasis prevents minor capillary bleeding.  

When secondary haemostasis is abnormal, larger bleeds are frequently seen. Haemothroax, haemoperitoneum, or haemoarthrosis may occur, in addition to subcutaneous and intramuscular haemorrhages. Petechia and ecchymoses are not usually apparent, as intact primary haemostasis prevents minor capillary bleeding.  

disroders of fibrinolysis may result in thrombus formation and loss of blood supply. The fomation of thrombi is promoted by: local endothelial injury (vascular damage), circulatory stasis and changed in anticoagulants or procoagulants, e.g. decreased ATIII. The most common mechanisms for AT deficiency are glomerular disease (AT is similar in size to albumin and is thus lost via the urine in glomerular diseasesP and accelarated consumption which occurs with disseminated intravascular coagulation or sepsis.

If fibrinolysis is defective, thrombus formation and infarctions may result. Thrombus formation may be promoted by vascular damage, circulatory stasis or changes in anticoagulants or procoagulants. For example, ATIII may be decreased. This can occur by loss due to glomerular disease or accelarated consumption in disseminated intravascular coagulation or sepsis.

==Tests Evaluating Primary Haemostasis==

==Tests Evaluating Primary Haemostasis==