Difference between revisions of "Systemic Lupus Erythematosus"
| Line 4: | Line 4: | ||
==Description== | ==Description== | ||
| − | Systemic Lupus Erythematous is an immune-mediated disease which can affect many different organ systems. The immune system is directed against various tissues of the body and immune complexes cause a type III hypersensitivity reaction. The condition is documented in cats and dogs but the etiology is not known. The disease has been reported in colonies of dogs suggesting that there may be a genetic or infectious component to the cause. | + | Systemic Lupus Erythematous is an immune-mediated disease which can affect many different organ systems. The immune system is directed against various tissues of the body and immune complexes cause a [[Type III Hypersensitivity|type III hypersensitivity reaction]]. The condition is documented in cats and dogs but the etiology is not known. The disease has been reported in colonies of dogs suggesting that there may be a genetic or infectious component to the cause. |
==Signalment== | ==Signalment== | ||
| Line 10: | Line 10: | ||
==Diagnosis== | ==Diagnosis== | ||
===Clinical Signs=== | ===Clinical Signs=== | ||
| + | Clinical signs depend on the tissues and organ systems affected by the condition. A combination of the following signs may be seen: | ||
| + | |||
| + | * Immune-medated haemolytic anaemia | ||
| + | * Immune-mediated throbocytopenia | ||
| + | * Polyarthritis | ||
| + | * Glomerulonephritis | ||
| + | * Vasculitis | ||
| + | * Dermatitis | ||
| + | * Seizures | ||
==Treatment== | ==Treatment== | ||
| Line 18: | Line 27: | ||
==References== | ==References== | ||
| − | |||
[[Category:Antibody Mediated Autoimmune Diseases]] | [[Category:Antibody Mediated Autoimmune Diseases]] | ||
[[Category:To Do - lizzyk]][[Category:To Do - Re]] | [[Category:To Do - lizzyk]][[Category:To Do - Re]] | ||
Revision as of 11:58, 14 September 2010
 |
This article is still under construction. |
Systemic Lupus Erythematosus is also known as SLE and Multi-systemic immune mediated disease
Description
Systemic Lupus Erythematous is an immune-mediated disease which can affect many different organ systems. The immune system is directed against various tissues of the body and immune complexes cause a type III hypersensitivity reaction. The condition is documented in cats and dogs but the etiology is not known. The disease has been reported in colonies of dogs suggesting that there may be a genetic or infectious component to the cause.
Signalment
Diagnosis
Clinical Signs
Clinical signs depend on the tissues and organ systems affected by the condition. A combination of the following signs may be seen:
- Immune-medated haemolytic anaemia
- Immune-mediated throbocytopenia
- Polyarthritis
- Glomerulonephritis
- Vasculitis
- Dermatitis
- Seizures
Treatment
Treatment is with immunosuppressive drugs. Corticosteroids are the most widely used immunosuppresives, predinoslone or dexamethasone is used alone or in combination with azothioprine or cyclophosphamide in more sereve cases. Typically the dose can be tapered once the condtion is under control.