Difference between revisions of "Thrombosis"

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Cardiac thrombosis is generally of degenerative/ non-infectious cause; endocarditis may occur, though uncommonly. There are important effects of cardiac thrombosis:
 
Cardiac thrombosis is generally of degenerative/ non-infectious cause; endocarditis may occur, though uncommonly. There are important effects of cardiac thrombosis:
 
# Distortion of valve cusps leads to mechanical effects which cause ineffective closure (incompetence), and distortion and enlargement of the valves by the thrombus mass causes narrowing of the valve outflow (stenosis). These effects lead to a progressive inefficiency of cardiac pumping and give rise to [[Venous Congestion and Hyperaemia - Pathology#Generalised (Systemic) Venous Congestion|general venous congestion]], [[Oedema - Pathology|oedema]] and circulatory failure.
 
# Distortion of valve cusps leads to mechanical effects which cause ineffective closure (incompetence), and distortion and enlargement of the valves by the thrombus mass causes narrowing of the valve outflow (stenosis). These effects lead to a progressive inefficiency of cardiac pumping and give rise to [[Venous Congestion and Hyperaemia - Pathology#Generalised (Systemic) Venous Congestion|general venous congestion]], [[Oedema - Pathology|oedema]] and circulatory failure.
*# Emboli are disseminated from the thrombus mass.
+
# Emboli can be disseminated from the thrombus mass. If the lesion is on the left side of the heart, emboli are disseminated systemically and become trapped in the capilarry beds, e.g. of the kidney and spleen. The blockage leads to local ischaemic necrosis. If the lesion is on the right side of the heart, there is pulmonary dissemination.
*#* If the lesion is on the left side of the heart, emboli are disseminated systemically.
 
*#** Become trapped in the capilarry beds, e.g. of the kidney and spleen.
 
*#*** Blockage leads to local ischaemic necrosis.
 
*#* If the lesion is on the right side of the heart, there is pulmonary dissemination.
 
 
[[Image:thrombosis dog nose 2.jpg|right|thumb|200px|<small><center>'''Nasal thrombosis (dog)'''. Courtesy of T. Scase</center></small>]]
 
[[Image:thrombosis dog nose 2.jpg|right|thumb|200px|<small><center>'''Nasal thrombosis (dog)'''. Courtesy of T. Scase</center></small>]]
 
====Atrial Thrombosis====
 
====Atrial Thrombosis====

Revision as of 14:14, 20 September 2010

Pulmonary artery thrombus. Courtesy of A. Jefferies

Introduction

Sarcoma embolus (dog). Courtesy of T. Scase

Thrombosis may be due to:

  • Endothelial injury.
  • Altered blood flow E.g. abnormal stasis.
  • Hypercoagulability.

Often associated with other disease processes such as disseminated intravascular coagulation (DIC).

Commonly see posterior paralysis of cats with cardiomyopathy.

Spontaneous venous thrombosis is rare. Seen in cattle with traumatic reticulo-peritonitis in the caudal vena cava.

Description

Thrombosis is a localized or generalized intravascular clot formation. Thrombi form as the result of trauma or pathological processes affecting the blood vessel endothelium or disturbances to blood flow and/or blood composition. Some diseases such as infective endocarditis and heart worm increase the risk of thrombi formation.

Diagnosis

History & Clinical Signs

  • Signs depend on the area affected and the size of the blocked vessel.
  • Poor perfusion below affected area.
  • Malfunction and necrosis of affected organs

Laboratory Findings

Abnormalities associated with lack of blood perfusion and/or pathological conditions.

Ultrasonography

  • Blood stasis
  • Visualization of a thrombus

Angiography

  • May show lack of opacity in affected region

Treatment

  • Treat underlying problem
  • Give IV Fluids
  • Use an anticoagulant (Heparin for short term treatment, Aspirin for long term treatment)

Prognosis

Prognosis depends upon the underlying condition.

Pathophysiology

Terminology

  • A thrombus is a solid blood clot that forms within the vessels or heart during life.
  • The process of thrombus formation is known as thrombosis.
  • Thrombii may occur anywhere within the cardiovascular system.

Thrombosis formation

DIC thrombus. Courtesy of A. Jefferies

The process usually begins with platelets becoming sticky. They adhere to each other and to the endothelium. This increased "stickiness" is induced by contact with:

  • Collagen
  • Basement membrane
  • Damaged endothelial cells
  • Bacteria

Microscopic Appearance of a Thrombus

A thrombus is a layered mass which is attached to the vessel wall. The composition consists of red blood cells, [[Neutrophils - WikiBlood|neutrophils]] and platelets bound together by fibrin.

Thrombi take different appareance depending on whether they are arterial or venous:

  • Arterial thrombi tend to be pale and have a tail in the direction of blood flow. The high rate of blood flow sweeps red cells away - the thrombus is composed of mainly white cells, platelets and fibrin which are left behind.
  • Venous thrombi tend to be a darker red. The slow blood flow allows the clot to form quicker which is loosely arranged and contains many red blood cells.

Causes of Thrombosis

Thrombosis is caused by any condition that allows platelets to adhere to the endothelial wall, including:

  • Damage to the vessel wall - when there is damage of the overlying endothelium, collagen is exposed and platelets will attach to this. The blood clotting process will occur, giving formation of an intraluminal blood clot. The process of formation occurs in phases giving a cross section of the clot a laminated appearance.

Vessel walls may be damaged in several ways:

  1. Trauma
  2. Localisation by colonies of bacteria
  3. Viral infection of endothelial cells
  4. Migration of parasites.
  5. Repeated puncture of the jugular vein is a common cause of serious or fatal thrombosis.
  • Changes in normal blood flow, including stasis, turbulence, and changes in blod composition.

Stasis prevents coaglation factors being cleared by the liver and reticuloendothelial system. Coagulation factors build up, leading to clot formation which quickly enlarges to fill the lumen. When stasis occurs in a vein, the thrombus forms behind the valve cusps.

Turbulence disrupts the laminar flow and may even damage the endothelium, allowing platelets to come into contact with the endothelial wall. Thrombi tend to form at arterial branches and venous junctions where there are eddy currents and local stasis.

Altered blood composition which can induce thrombosis includes an increase in the number and adhesiveness of platelets, or in plasma fibrin and clotting factors, resulting in a hypercoagulateable state. There may also be a decrease in the activity of the fibrinolyltic system. This may be caused by surgical or traumatic shock, or inflammation with toxaemia.

Types of Thrombosis

Arterial Thrombosis

Although this is common in man, it is uncommon in domestic animals; in man it is associated with atherosclerotic vascular disease. When they do occur in animals, arterial thrombi are usually small lesions but these may be sited strategically, thereby causing problems.

Arteriosclerosis

Seen in aged dogs and horses affecting the coronary artery and other major arteries.

Verminous arteritis

May occur with or without aneurysm and is seen in horses as a result of Strongylus vulgaris infestation. Affects the root of cranial mesenteric artery, renal artery and aorta as a consequence of larval migration in the vessel walls.

Iliac thrombosis

Seen in cats in the UK, and often referred to as a "saddle embolus", this condition is associated with cardio-myopathy and atrial thrombosis.

Cardiac Thrombosis

Cardiac thrombosis is usually valvular, but can occasionally be mural.

Species specific Thrombi

Farm Species

In farm animals, and rarely in the horse, infective/ inflammatory thrombosis occurs subsequent to endocarditis.

Dogs and Horse

Nasal thrombosis (dog). Courtesy of T. Scase

Cardiac thrombosis is generally of degenerative/ non-infectious cause; endocarditis may occur, though uncommonly. There are important effects of cardiac thrombosis:

  1. Distortion of valve cusps leads to mechanical effects which cause ineffective closure (incompetence), and distortion and enlargement of the valves by the thrombus mass causes narrowing of the valve outflow (stenosis). These effects lead to a progressive inefficiency of cardiac pumping and give rise to general venous congestion, oedema and circulatory failure.
  2. Emboli can be disseminated from the thrombus mass. If the lesion is on the left side of the heart, emboli are disseminated systemically and become trapped in the capilarry beds, e.g. of the kidney and spleen. The blockage leads to local ischaemic necrosis. If the lesion is on the right side of the heart, there is pulmonary dissemination.
Nasal thrombosis (dog). Courtesy of T. Scase

Atrial Thrombosis

  • Uncommon.
    • Seen rarely in cats and dogs.
  • Results from stasis in atrial appendages.

Venous Thrombosis

Description

  • Thrombus formation in the venous system occurs most commonly as the result of trauma, venous catheterisation, or neoplastic conditions.


  • Obstruction of the affected area or embolisation of the thrombus to distant areas results in a variety of clinical signs. As could be expected, the location of the insult determines the type of presenting signs. For example, pulmonary emboli cause respiratory problems while portal vein thrombi result in ascites and the possible development of hepatic encephalopathy or portosystemic shunting.
  • Venous thrombosis is a fairly common type of thrombus in the veterinary species.
    • This is because:
      1. Veins are relatively thin-walled.
        • Are therefore more susceptible to distortion, inflammatory damage and iatrogenic vene puncture damage.
      2. Veins have relatively slower blood flow rates.
        • Cell aggregates tend to persist more readily.
  • Most venous thrombosis in domestic animals results from :
    • Extension of inflammatory reactions.
    • Erosion/disruption caused by malignant tumours.
    • Pressure from adjacent space-occupying masses.
    • Vene puncture damage.

Capillary Thrombosis

  • These are microthrombi.
    • Only appreciable histologically.
  • Formation may be:
    • Localised
      • Associated with acute local inflammation.
      • Not very significant unless strategically sited.
    • Generalised

Evolution of a Thrombus

  • If the animal survives the immediate effects of a thrombus, the thrombus may evolve in one of the following ways:
  1. The thrombus may gradually enlarge and eventually cause total obstruction of a vessel.
  2. The thrombus may be completely removed by fibrinolytic activity.
    • Fibrinolysis is a very active process - clots are usually removed within a few days of formation.
    • Blood flow is crucial to the process of fibrinolysis.
      • An occlusive thrombus may prevent the necessary enzymes from reaching the clot.
    • To overcome occlusion, contraction of fresh clots under the influence of thrombasthenin (released by platelets) forms a slit-like channel beside the thrombus.
      • The blood that then flows past may completely dissolve the clot.
  3. Organisation
    • A thrombus acts as a foreign body, causing an inflammatory response in the underlying blood vessel or heart wall.
    • The external surface of the thrombus quickly becomes covered by endothelium.
      • Is excluded from the clotting mechanism.
    • Neutrophils invade the mass and may digest the centre.
      • Occasionally, subsequent invasion by bacteria may lead to to purulent inflammation.
      • Normally, fibroblasts and capillary buds follow the neutrophils into the thrombus and a fibrous vascularised connective tissue forms.
        • Capillaries channels anastomose to produce vessels that traverse the thrombus and re-establish blood flow.
          • This is known as canalisation of a thrombus.
        • Fibrous tissue matures and contracts, eventually causing the thrombus to become incorporated into the vessel wall as a fibrous lump.
  4. A piece of the thrombus may break off and form an embolus.