Difference between revisions of "Phosphorus"

Revision as of 20:42, 5 November 2010

Phosphorus

Phosphorus is the third most abundent intracellular ion:

Potassium
Magnesium
Phosphorus (as Phosphate)

Within the body it is found as Phosphate ions or Phosphate within bone. The majority (~95%) is combined with Calcium in bone, forming Hydroxyapatite. Less than 1% is found in the extracelullar fluid.

Homeostasis

Serum concentrations of phosphorus are maintained by dietary sources. It is absorbed across the intestine via Passive diffusion and Vitamin D mediated active transport.

Phosphorus is excreted in the urine or saliva (particularly in ruminants).

Hormonal Regulation

PTH

Mobilises phosphorus from bone, acting to increase plasma concentration of P
Increases phosphorus loss in the urine and saliva, acting to decrease plasma concentration

So ultimately, PTH acts to remove phosphorus from the body entirely.

Calcitriol

Increases phosphorus absorbtion from the intestines

Pathology

Diseases relating to phosphorus homeostasis include:

Primary and Secondary Hyperparathyroidism
Hyperphosphataemia
Hypophosphatemia

Test yourself with the Phosphorus Homeostasis Flashcards

Phosphorus Homeostasis Flashcards

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-Hyperphosphataemia occurs from excessive dietary phosphorus, hypervitaminosis D and renal disease. Phosphorus may be the only biochemical parameter increased in renal failure. Hypophosphataemia may occur with anorexia, starvation or other nutritional imbalances. A calcium:phosphorus ratio of less than 1:1 is suggestive of renal disease.
+==Phosphorus==
-[[Category:Lizard_and_Snake_Glossary]]
+Phosphorus is the third most abundent intracellular ion:
+#Potassium
+#Magnesium
+#Phosphorus (as Phosphate)
+Within the body it is found as Phosphate ions or Phosphate within bone.
+The majority (~95%) is combined with Calcium in bone, forming Hydroxyapatite. Less than 1% is found in the extracelullar fluid.
+==Homeostasis==
+Serum concentrations of phosphorus are maintained by dietary sources. It is absorbed across the intestine via ''Passive diffusion'' and ''[[Calcium#Calcitriol (Active Vitamin D3)|Vitamin D]] mediated active transport''.
+Phosphorus is excreted in the urine or saliva (particularly in ruminants).
+===Hormonal Regulation===
+[[Calcium#Parathyroid Hormone (PTH)|'''PTH''']]
+*Mobilises phosphorus from bone, acting to increase plasma concentration of P
+*Increases phosphorus loss in the urine and saliva, acting to decrease plasma concentration
+So ultimately, PTH acts to remove phosphorus from the body entirely.
+[[Calcium#Calcitriol (Active Vitamin D3)|'''Calcitriol''']]
+*Increases phosphorus absorbtion from the intestines
+==Pathology==
+Diseases relating to phosphorus homeostasis include:
+*[[Bones Metabolic - Pathology#Primary hyperparathyroidism |Primary and Secondary Hyperparathyroidism]]
+*[[Kidney Renal Failure - Pathology#Uraemia |Hyperphosphataemia]]
+*Hypophosphatemia
+==Test yourself with the Phosphorus Homeostasis Flashcards==
+[[Phosphorus_Homeostasis_Flash_Cards_-_Anatomy_%26_Physiology|Phosphorus Homeostasis Flashcards]]
+[[Category:Endocrine System - Anatomy & Physiology]]
+[[Category:Electrolytes]]