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[[Liver_Flashcards_-_Pathology|Liver Pathology Flashcards]]
[[Liver_Flashcards_-_Pathology|Liver Pathology Flashcards]]
(LSD)
* Occurs in many breeds of dogs and cats.
* Genetic defects give deficiencies of specific enzymes of degradation.
** Disease only occurs in animals homozygous at the gene pair controlling enzyme activity.
*** The genes are co-dominant.
** Enzyme activity is extremely low or entirely absent.
* Large amounts of waste products accumulate within cells.
** Nervous system cells are predisposed.
** Cells become engorged.
** Normal function is prevented.
* [http://w3.vet.cornell.edu/nst/nst.asp?Fun=Display&imgID=20531 Image 1, courtesy of Cornell Veterinary Medicine] <BR>
* [http://w3.vet.cornell.edu/nst/nst.asp?Fun=Display&imgID=20530 Image 2, courtesy of Cornell Veterinary Medicine]
* [http://w3.vet.cornell.edu/nst/nst.asp?Fun=Display&imgID=20185 Image 3, courtesy of Cornell Veterinary Medicine]
===Clinical Signs===
* Nervous system cells are predisposed to the disease, and so progressive neurological signs predominate.
** Develop between 2 weeks and 12 months of age.
** The disease is ultimately fatal.
* For example, Siamese cats show:
** Ganglisidosis
** Mucopolysaccharidosis
===Diagnosis===
* Clinical signs are considered.
* Urine enzyme assays may be helpful.
* Post-mortem diagnosis is possible.
* More recently, gene tests have been available.
==References==
==References==
[[Category:Central Nervous System - Degenerative Pathology]]
[[Category:Liver - Storage Diseases]]
[[Category:Liver - Storage Diseases]]
[[Category:To_Do_-_Clinical]]
[[Category:To_Do_-_Clinical]]