Changes

This is another example of the immune system working through the innate immune response, and this can even act to suppress antibody synthesis.

This is another example of the immune system working through the innate immune response, and this can even act to suppress antibody synthesis.

==TH₂ Cells==

==T_H2 Cells==

[[Image:TH2-Bcell.jpg|thumb|right|200px|TH2 cells incite increased antibody production - B. Catchpole, RVC 2008]]

[[Image:TH2-Bcell.jpg|thumb|right|200px|TH2 cells incite increased antibody production - B. Catchpole, RVC 2008]]

TH₂ cells help [[B cells]] produce antibody where the organism is present in tissue fluid. The TH₂ population influences B cell activation, proliferation and immunoglobulin production. TH₂ T cells also secrete a range of cytokines:

T_H2 cells help [[B cells]] produce antibody where the organism is present in tissue fluid. The T_H2 population influences B cell activation, proliferation and immunoglobulin production. T_H2 T cells also secrete a range of cytokines:

#'''IL-4''' which stimulates B cell growth and induces the heavy chain switch from [[Immunoglobulin M|IgM]] to [[Immunoglobulin G|IgG]] , [[Immunoglobulin A|IgA]] and [[Immunoglobulin E|IgE]], as well as proliferation of basophils and mast cells. IL-4 can inhibit some T cell responses.

#'''IL-4''' which stimulates B cell growth and induces the heavy chain switch from [[Immunoglobulin M|IgM]] to [[Immunoglobulin G|IgG]] , [[Immunoglobulin A|IgA]] and [[Immunoglobulin E|IgE]], as well as proliferation of basophils and mast cells. IL-4 can inhibit some T cell responses.

#'''IL-5''' which activates B cells and stimulates a high rate of proliferation. IL-5 also promotes immunoglobulin synthesis and the proliferation and differentiation of eosinophils.

#'''IL-5''' which activates B cells and stimulates a high rate of proliferation. IL-5 also promotes immunoglobulin synthesis and the proliferation and differentiation of eosinophils.