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**LPS O antigens prevent damage to bacterial cell wall by complement
 
**LPS O antigens prevent damage to bacterial cell wall by complement
 
**LPS also causes endotoxaemia, and may contribute to local inflammatory response damaging intestinal cells to cause diarrhoea
 
**LPS also causes endotoxaemia, and may contribute to local inflammatory response damaging intestinal cells to cause diarrhoea
**Endotoxic shock during septicaemic [[Intestines - Fibrinous/ Haemorrhagic Enteritis#Salmonellosis|salmonellosis]] due to LPS  
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**Endotoxic shock during septicaemic [[Intestines Fibrinous/Haemorrhagic Enteritis - Pathology#Salmonellosis|salmonellosis]] due to LPS  
 
**Septicaemia may cause [[Bacterial skin infections - Pathology#Systemic bacterial infections|cyanosis of extremities]]
 
**Septicaemia may cause [[Bacterial skin infections - Pathology#Systemic bacterial infections|cyanosis of extremities]]
 
**Intracellular carriage if bacteria no completely removed
 
**Intracellular carriage if bacteria no completely removed
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*Most human infections contracted from animals, especially poulty and cattle
 
*Most human infections contracted from animals, especially poulty and cattle
 
*Some serotypes are host-specific, some infect a wide range of species
 
*Some serotypes are host-specific, some infect a wide range of species
*Healthy adult carnivores are resistant to [[Intestines - Fibrinous/ Haemorrhagic Enteritis#Salmonellosis|salmonellosis]]
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*Healthy adult carnivores are resistant to [[Intestines Fibrinous/Haemorrhagic Enteritis - Pathology#Salmonellosis|salmonellosis]]
 
*Clinical outcome depends on number of bacteria ingested, virulence of serotype, susceptibility of host
 
*Clinical outcome depends on number of bacteria ingested, virulence of serotype, susceptibility of host
 
*Young and debilitated animals susceptible
 
*Young and debilitated animals susceptible
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**''S.'' Typhi, ''S.'' Paratyphi: infect humans
 
**''S.'' Typhi, ''S.'' Paratyphi: infect humans
 
**''S.'' Montevideo produces outbreaks from contaminated imported meat and bone meal  
 
**''S.'' Montevideo produces outbreaks from contaminated imported meat and bone meal  
*Enteric [[Intestines - Fibrinous/ Haemorrhagic Enteritis#Salmonellosis|salmonellosis]]:
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*Enteric [[Intestines Fibrinous/Haemorrhagic Enteritis - Pathology#Salmonellosis|salmonellosis]]:
 
**Enterocolitis occurs in most farm animal species affecting all ages
 
**Enterocolitis occurs in most farm animal species affecting all ages
 
**[[Intestines - Ulcerative Enteritis|Ulcerative enteritis]]  
 
**[[Intestines - Ulcerative Enteritis|Ulcerative enteritis]]  
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**Milder syndrome where endemic on farms, possibly due to acquired immunity
 
**Milder syndrome where endemic on farms, possibly due to acquired immunity
 
**Chronic enterocolitis can occur in surviving pigs, cattle, horses, causing intermittent fever, soft faeces and gradual weight loss
 
**Chronic enterocolitis can occur in surviving pigs, cattle, horses, causing intermittent fever, soft faeces and gradual weight loss
*Septicaemic [[Intestines - Fibrinous/ Haemorrhagic Enteritis#Salmonellosis|salmonellosis]]:
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*Septicaemic [[Intestines Fibrinous/Haemorrhagic Enteritis - Pathology#Salmonellosis|salmonellosis]]:
 
**Most common in calves, neonatal foals, pigs under one month
 
**Most common in calves, neonatal foals, pigs under one month
 
**Sudden onset fever, depression, recumbency
 
**Sudden onset fever, depression, recumbency
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**Can cause haemorrhagic disease by [[General Pathology - Haemostasis#Secondary Thrombocytopenic Disease|secondary thrombocytopenic disease]]
 
**Can cause haemorrhagic disease by [[General Pathology - Haemostasis#Secondary Thrombocytopenic Disease|secondary thrombocytopenic disease]]
 
**''S.'' Cholerae-Suis in pigs causes blue discoloration of ears and snout; co-infection with viruses causes severe clinical forms of disease
 
**''S.'' Cholerae-Suis in pigs causes blue discoloration of ears and snout; co-infection with viruses causes severe clinical forms of disease
*Bovine [[Intestines - Fibrinous/ Haemorrhagic Enteritis#Salmonellosis|salmonellosis]]:
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*Bovine [[Intestines Fibrinous/Haemorrhagic Enteritis - Pathology#Salmonellosis|salmonellosis]]:
 
**Syndrome of fever and diarrhoea (with dysentery), often fatal, in calves and adult cattle
 
**Syndrome of fever and diarrhoea (with dysentery), often fatal, in calves and adult cattle
 
**Abdominal pain in adult cattle due to necrotic bowel
 
**Abdominal pain in adult cattle due to necrotic bowel
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***Most survivors become subclinical excretors
 
***Most survivors become subclinical excretors
 
***May become latent carriers with no excretion
 
***May become latent carriers with no excretion
*<div id="Spleen">[[Intestines - Fibrinous/ Haemorrhagic Enteritis#Salmonellosis|Salmonellosis]] in poultry:
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*<div id="Spleen">[[Intestines Fibrinous/Haemorrhagic Enteritis - Pathology#Salmonellosis|Salmonellosis]] in poultry:
 
**''S.'' Pullorum and ''S.'' Gallinarum now rare in UK due to eradication programs including the Pullorum test (whole blood slide agglutination to detect antibody to both ''S.'' Pullorum and ''S'' Gallinarum)
 
**''S.'' Pullorum and ''S.'' Gallinarum now rare in UK due to eradication programs including the Pullorum test (whole blood slide agglutination to detect antibody to both ''S.'' Pullorum and ''S'' Gallinarum)
 
**These ''Salmonellae'' can infect the ovaries of hens and be transmitted via eggs
 
**These ''Salmonellae'' can infect the ovaries of hens and be transmitted via eggs

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