Changes

**3-7 days: ruptured vesicles, loss of epithelia, no marked fibrous margin

**3-7 days: ruptured vesicles, loss of epithelia, no marked fibrous margin

**7-10+ days: open lesions with marked fibrous  margin

**7-10+ days: open lesions with marked fibrous  margin

*Prevalence of lesions by species:

*In the young, without maternal antibody, virus will localize in the heart and cause death by myocarditis

**'''Pigs''':  

*FMDV causes '''loss of condition and productivity''' but is NOT typically fatal

***Lesion at '''coronary band''' means infection is usually less than a week old

 

***Lesions grow down claw at a rate of 1mm per week

=====Pathogenesis by species=====

**'''Cattle'''

*'''Pigs''' and '''Sheep''':  

***

**Lesions less obvious, but vesicles around nose, mouth, and coronary band

**Lesion at '''coronary band''' means infection is usually less than a week old

**Lesions grow down claw at a rate of 1mm per week

*'''Cattle'''

**Lesions are seen inside mouth, around muzzle, in the interdigital cleft, around coronary band, and on teats

**PM: lesions in oesophagus and forestomachs

 

====Epidemiology====

====Epidemiology====