Difference between revisions of "Testicular Feminisation"
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== Aetiology == | == Aetiology == | ||
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| − | [[Category:Reproductive | + | [[Category:Reproductive Disorders]] |
Revision as of 14:44, 7 December 2010
Aetiology
- Genotype XY as should be in the male.
- Testes develop normally and secrete Androgens and MIH
- Foetal genetalia are genetically insensitive to the actions of Androgens due to a point mutation in the Androgen receptor.
Consequence
- Wolffian Ducts regress, allowing formation of female external genetalia:
- Labia
- Clitoris
- Vagina
- Sertoli cells are present and continue to secrete MIH, causing Mullarian Duct regression.
- Since both Wolffian AND Mullarian Ducts regress, there is no internal genetalia.