Difference between revisions of "Skin Immunologic - Pathology"

Revision as of 16:54, 22 February 2011

Classification:
- Hypersensitivity - response to normally harmless substances
- Auto-immune - antobodies or T-cells reactive against self-antigens
Mostly involves mixture of types described below

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 ===[[Systemic Lupus Erythematosus]]===
-*'''Systemic (SLE)'''
-**Multiple organs involved
-**Cats, dogs, horses
-**Immune dysregulation:
-***Damaged T-cell suppressor function, either primary deficiency or antibody mediated
-***Cytokine dysregulation
-***Resulting B-cell hyperactivity -> antibodies to self antigens -> antigen-antibody complexes deposited in various tissues -> Type III hypersensitivity
-**Lesions localised or generalised
-**Erythema, alopecia, depigmentation, crusting and scaling, ulceration
-**Microscopically: lymphohistiocytic interface dermatitis, thickened basement membrane, vasculitis, subepidermal vesicles, basal cell degeneration
-*'''Discoid'''
-**Milder variant of systemic
-**Depigmentation, erythema, scaling, erosions, ulceration, crusting
-**Usually involves nasal planum, dorsum of muzzle, occasionally pinnae, lips, oral mucosa or periocular area
-**Microscopically: lichenoid interface dermatitis, often with lymphocytes, plasma cells, basal cell degeneration, loss of pigment
-[[Category:Integumentary System - Autoimmune Reactions]]
 ===[[Pemphigus]]===