Difference between revisions of "Muscles Developmental - Pathology"

Revision as of 17:31, 3 March 2011

Acquired
- Autoimmune disease
  - Antibodies directed against acetyl choline receptors
- Associated with thymomas, megaoesophagus and dysphagia
- In adult dogs
Congenital
- Inherited deficiency in acetyl choline receptors
- Rare
- Newfoundland, Jack Russel Terrier, Springer Spaniels – genetic predisposition
- In dogs – 4 DLA genes recognized: DLA-12, DLA-88, DLA-79 and DLA-64
- Associated with HLA gene in humans
- No antibodies against acetyl choline receptors in serum
- Non-specific muscle disuse atrophy and fibrosis or no changes on histology
Both forms manifest as weakness which worsens on exercise

@@ Line 14: / Line 14: @@
-===Glycogen storage diseases===
+===[[Glycogen Storage Disease]]===
-*Caused by a deficiency of an enzyme
-*See [[Glycogen Infiltration|general pathology]]
-*Type II glycogenosis
-**Deficiency of acid maltase
-**In Shorthorn cattle
-**Muscular weakness and incoordination
-**Glycogen stored in skeletal muscle, heart and CNS
-**Type I and II muscle fibres contain glycogen vacuoles
-*Type III glycogenosis
-**Deficiency of debranching enzyme
-**In dogs
-**Causes [[Hypertrophic Cardiomyopathy|hypertrophic cardiomyopathy]] and hepatomegaly
-**Glycogen in skeletal and cardiac muscle, neurons nad hepatocytes
-[[Category:Muscles - Developmental Pathology]]