Difference between revisions of "Muscle Necrosis"

Revision as of 18:29, 3 March 2011

Necrosis of an entire myofibre is uncommon
Segmental necrosis is more typical
Muscle cell contents may leak into the blood if the cell membrane is damaged
Creatine kinase (CK) is an enzyme which leaks following injury
- Used to measure the extent of muscle damage
Often is followed by regeneration
Histologically:
- Hyaline hypercontracted fiber rounded at cross-section and increased diameter and eosin staining
  - May also be an artifact due to hypercontraction of normal fibres at fixation
- Fragmenting portions of fibre -> floccular or granular
- Normal portion of fibre may detach from necrotic part -> retraction caps
- Infarction may cause discoid degeneration - necrotic fibres detach at Z lines
- May mineralise
Zenker's degeneration - secondary to systemic disease
- Scattered small segments of necrosis and fast regeneration
- Sacrolemmal tubes are intact

@@ Line 11: / Line 11: @@
 **Normal portion of fibre may detach from necrotic part -> retraction caps
 **Infarction may cause '''discoid degeneration''' - necrotic fibres detach at '''Z lines'''
-**May [[Muscles Degenerative - Pathology#Calcification|mineralise]]
+**May [[Muscle Calcification|mineralise]]
 *[[Zenker Degeneration - Pathology|'''Zenker's degeneration''']] - secondary to systemic disease
 **Scattered small segments of necrosis and fast regeneration