Difference between revisions of "Butyrophenones"
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==Side Effects and Contraindications== | ==Side Effects and Contraindications== | ||
| − | Adverse effects in the CNS may occur, for example hallucinations and agitation have been reported in man. Vasodilation and hypotension also result from | + | Adverse effects in the CNS may occur, for example hallucinations and agitation have been reported in man. Vasodilation and hypotension also result from administration. |
==Drugs in this Group== | ==Drugs in this Group== | ||
Latest revision as of 21:34, 17 November 2013
Butyrophenones are sedative drugs, which have a potent anti-emetic effect.
Mechanism of Action
Butyrophenones antagonise dopamine transmission in the CNS.
Side Effects and Contraindications
Adverse effects in the CNS may occur, for example hallucinations and agitation have been reported in man. Vasodilation and hypotension also result from administration.
Drugs in this Group
- Azaperone
- Fluanisone
- Droperidol
Azaperone
Azaperone is marketed under the trade name of Stresnil. It modifies behaviour and gives dose-related sedation. It is used in pigs, for example against aggresssion and transport stress, to aid obstetrical intervention and as a premedicant. Intramuscular administration is preferred, with a 20 minute onset time (this is 5 mins if given i/v). The effects last 2-6 hours, and the drug potentiates anaesthetic agents.