Difference between revisions of "Adrenogenital Syndrome"
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| − | ''''' | + | <big><center>[[Reproductive System|'''BACK TO REPRODUCTIVE SYSTEM''']]</center></big> |
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| + | <big><center>[[Reproductive_System#Fertilisation.2C_Implantation_and_Early_Embryonic_Development|'''BACK TO FERTILISATION , IMPLANTATION and EARLY EMBRYONIC DEVELOPMENT''']]</center></big> | ||
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| + | <big><center>[[Fertilisation%2C_Implantation_and_Early_Embryonic_Development_-Sexual_Differentiation-_Anatomy_%26_Physiology#Associated_Disorders|'''BACK TO SEXUAL DIFFERENTIATION''']]</center></big> | ||
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| + | == Aetiology == | ||
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* Genotype is XX as should be female | * Genotype is XX as should be female | ||
* Ovaries develop normally | * Ovaries develop normally | ||
* Foetal [[Endocrine_System_-_Adrenal_Glands_-_Anatomy_%26_Physiology|Adrenal Gland]] is hyperactive and secretes large quantities of Adrenal Androgens, due to a '''21 hydroxylase mutation'''. | * Foetal [[Endocrine_System_-_Adrenal_Glands_-_Anatomy_%26_Physiology|Adrenal Gland]] is hyperactive and secretes large quantities of Adrenal Androgens, due to a '''21 hydroxylase mutation'''. | ||
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| + | ---- | ||
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| − | + | == Consequence == | |
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* Wolffian Ducts persist due to the presence of Androgens, thus allowing development of '''male internal and external genitalia'''. | * Wolffian Ducts persist due to the presence of Androgens, thus allowing development of '''male internal and external genitalia'''. | ||
* Mullarian Ducts persist due to the absence of testes, hence absence of Sertoli cell MIH secretion. This allows formation of '''female internal genitalia'''. | * Mullarian Ducts persist due to the absence of testes, hence absence of Sertoli cell MIH secretion. This allows formation of '''female internal genitalia'''. | ||
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| + | ---- | ||
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| + | == Morphology == | ||
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* Appears male with a '''micropenis and scrotum''' | * Appears male with a '''micropenis and scrotum''' | ||
* Both male and female internal genitalia | * Both male and female internal genitalia | ||
Revision as of 11:18, 15 July 2008
Aetiology
- Genotype is XX as should be female
- Ovaries develop normally
- Foetal Adrenal Gland is hyperactive and secretes large quantities of Adrenal Androgens, due to a 21 hydroxylase mutation.
Consequence
- Wolffian Ducts persist due to the presence of Androgens, thus allowing development of male internal and external genitalia.
- Mullarian Ducts persist due to the absence of testes, hence absence of Sertoli cell MIH secretion. This allows formation of female internal genitalia.
Morphology
- Appears male with a micropenis and scrotum
- Both male and female internal genitalia