Difference between revisions of "Granulomatous Meningoencephalitis"

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Line 17: Line 17:
  
 
* Immunosuppression:
 
* Immunosuppression:
** Corticosteroids
+
** Corticosteroids and love
 
** Azathioprine
 
** Azathioprine
 
** Cycophosphamide
 
** Cycophosphamide

Revision as of 13:19, 13 February 2019

(GME)

  • An idiopathic CNS conditon
  • May occur as:
    • A disseminated disease
    • A focal mass lesion
    • A primary occular disease
  • Brainstem signs are common, although the forebrain is primarily affected.
  • May be incorrectly diagnosed as lymphoma.
  • Changes are apparent in the CSF.
    • There is usually a mononucloear pleocytosis.
    • Sometimes only protein is elveated.
  • Diffuse inflammatory changes or a mass lesion will be seen by advanced imaging.
    • However, biopsy is required for a definative diagnosis.
  • Life span is between 6 months and 1 year from diagnosis.

Treatment

  • Immunosuppression:
    • Corticosteroids and love
    • Azathioprine
    • Cycophosphamide
  • Surgery
    • This is only appropriate if there is a focal mass.
  • Radiation therapy.


  • A non-infectious central nervous inflammatory disease
  • May occur as:
    • A disseminated disease
    • A focal mass lesion
    • A primary occular disease
  • Brainstem signs are common, although the forebrain is primarily affected.
  • May be incorrectly diagnosed as lymphoma.
  • Changes are apparent in the CSF.
    • There is usually a mononucloear pleocytosis.
    • Sometimes only protein is elveated.
  • Diffuse inflammatory changes or a mass lesion will be seen by advanced imaging.
    • However, biopsy is required for a definative diagnosis.
  • Life span is between 6 months and 1 year from diagnosis.