Granulomatous Meningoencephalitis
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(GME)
- An idiopathic CNS conditon
- May occur as:
- A disseminated disease
- A focal mass lesion
- A primary occular disease
- Brainstem signs are common, although the forebrain is primarily affected.
- May be incorrectly diagnosed as lymphoma.
- Changes are apparent in the CSF.
- There is usually a mononucloear pleocytosis.
- Sometimes only protein is elveated.
- Diffuse inflammatory changes or a mass lesion will be seen by advanced imaging.
- However, biopsy is required for a definative diagnosis.
- Life span is between 6 months and 1 year from diagnosis.
Treatment
- Immunosuppression:
- Corticosteroids
- Azathioprine
- Cycophosphamide
- Surgery
- This is only appropriate if there is a focal mass.
- Radiation therapy.
- A non-infectious central nervous inflammatory disease
- May occur as:
- A disseminated disease
- A focal mass lesion
- A primary occular disease
- Brainstem signs are common, although the forebrain is primarily affected.
- May be incorrectly diagnosed as lymphoma.
- Changes are apparent in the CSF.
- There is usually a mononucloear pleocytosis.
- Sometimes only protein is elveated.
- Diffuse inflammatory changes or a mass lesion will be seen by advanced imaging.
- However, biopsy is required for a definative diagnosis.
- Life span is between 6 months and 1 year from diagnosis.