Difference between revisions of "Testicular Feminisation"
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| − | + | {{toplink | |
| − | + | |backcolour =EED2EE | |
| − | + | |linkpage =Reproductive System - Anatomy & Physiology | |
| − | + | |linktext =Reproductive System | |
| − | + | |maplink = Reproductive System (Content Map) - Anatomy & Physiology | |
| − | + | |pagetype =Anatomy | |
| − | + | |sublink1=Reproductive System - Anatomy & Physiology#Fertilisation.2C Implantation and Early Embryonic Development | |
| − | + | |subtext1=FERTILISATION , IMPLANTATION AND EARLY EMBRYONIC DEVELOPMENT | |
| − | + | |sublink2=Fertilisation, Implantation and Early Embryonic Development -Sexual Differentiation- Anatomy & Physiology | |
| − | + | |subtext2=SEXUAL DIFFERENTIATION | |
| + | }} | ||
| + | <br> | ||
== Aetiology == | == Aetiology == | ||
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* Testes develop normally and secrete Androgens and MIH | * Testes develop normally and secrete Androgens and MIH | ||
* Foetal genetalia are genetically insensitive to the actions of Androgens due to a point mutation in the Androgen receptor. | * Foetal genetalia are genetically insensitive to the actions of Androgens due to a point mutation in the Androgen receptor. | ||
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== Consequence == | == Consequence == | ||
Revision as of 13:37, 3 September 2008
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Aetiology
- Genotype XY as should be in the male.
- Testes develop normally and secrete Androgens and MIH
- Foetal genetalia are genetically insensitive to the actions of Androgens due to a point mutation in the Androgen receptor.
Consequence
- Wolffian Ducts regress, allowing formation of female external genetalia:
- Labia
- Clitoris
- Vagina
- Sertoli cells are present and continue to secrete MIH, causing Mullarian Duct regression.
- Since both Wolffian AND Mullarian Ducts regress, there is no internal genetalia.