Difference between revisions of "Immunoglobulins Flashcards"

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==<font color="purple">Immunoglobulins Classes</font>==
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==<font color="purple">Classes of Immunoglobulin</font>==
 
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!width="400"|'''Question'''
 
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|<big>'''What are immunoglobulins also known as?'''
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|<big>'''How do the five classes of immunoglobulins vary from each other?'''
 
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*'''''Antibodies'''''
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*'''''They each have a different composition to their heavy chains'''''
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||[[Immunoglobulins - WikiBlood#Introduction|<span title="Answer article">Link to Answer Article</span>]]
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||[[Immunoglobulins - WikiBlood#Classes|<span title="Answer article">Link to Answer Article</span>]]
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|-
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|<big>'''IgA is specially adapted for function at which type of surface?'''
 +
||<font color="white"> <big>
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*'''''Mucosal surfaces'''''
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||[[Immunoglobulin A - WikiBlood|<span title="Answer article">Link to Answer Article</span>]]
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|-
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|<big>'''True or False: IgA is a monomer'''
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||<font color="white"> <big>
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*'''''False'''''
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*'''''IgA is a dimer'''''
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||[[Immunoglobulin A - WikiBlood#Structure|<span title="Answer article">Link to Answer Article</span>]]
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|-
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|<big>'''What are the functions of IgA?'''
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||<font color="white"> <big>
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*'''''Prevents agents from adhering to the epithelial surfaces as it binds to foreign antigen'''''
 +
*'''''Resists proteolytic digestion so can function in the gut'''''
 +
*'''''Does not activate the complement system so helps to preserve mucosal integrity'''''
 +
||[[Immunoglobulin A - WikiBlood#Function|<span title="Answer article">Link to Answer Article</span>]]
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|-
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|<big>'''In which species has IgD been identified?'''
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||<font color="white"> <big>
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*'''''Ruminants'''''
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*'''''Pigs'''''
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*'''''Dogs'''''
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*'''''Rodents'''''
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||[[Immunoglobulin D - WikiBlood#Function|<span title="Answer article">Link to Answer Article</span>]]
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|-
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|<big>'''What is the main function of IgD?'''
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||<font color="white"> <big>
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*'''''Helps B cell development'''''
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||[[Immunoglobulin D - WikiBlood#Function|<span title="Answer article">Link to Answer Article</span>]]
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|-
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|<big>'''True or False: IgE is not a soluble antibody?'''
 +
||<font color="white"> <big>
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*'''''True'''''
 +
||[[Immunoglobulin E - WikiBlood|<span title="Answer article">Link to Answer Article</span>]]
 +
|-
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|<big>'''What are the functions of IgE?'''
 +
||<font color="white"> <big>
 +
*'''''Triggers acute inflammation by causing degranulation'''''
 +
*'''''Involved in type I hypersensitivity reactions'''''
 +
*'''''Involved in producing immunity to parasitic worms and nematode parasites'''''
 +
||[[Immunoglobulin E - WikiBlood#Function|<span title="Answer article">Link to Answer Article</span>]]
 +
|-
 +
|<big>'''True or False: IgG is the smallest antibody and can easily leave the plasma and enter tissue?'''
 +
||<font color="white"> <big>
 +
*'''''True'''''
 +
||[[Immunoglobulin G - WikiBlood|<span title="Answer article">Link to Answer Article</span>]]
 +
|-
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|<big>'''Where is IgG produced?'''
 +
||<font color="white"> <big>
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*'''''Bone marrow'''''
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*'''''Spleen'''''
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*'''''Lymph nodes'''''
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||[[Immunoglobulin G - WikiBlood#Production|<span title="Answer article">Link to Answer Article</span>]]
 +
|-
 +
|<big>'''What is the function of IgG?'''
 +
||<font color="white"> <big>
 +
*'''''Activates the classical pathway of the complement cascade'''''
 +
*'''''Can act as targets for macrophages, eosinophils and neutrophils'''''
 +
*'''''Causes agglutination and opsonisation of bacteria'''''
 +
||[[Immunoglobulin G - WikiBlood#Function|<span title="Answer article">Link to Answer Article</span>]]
 
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'''START HERE TOMORROW WITH IG M'''
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<br>
 
<br>
 
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==<font color="purple">Immunoglobulins Variation</font>==
 
==<font color="purple">Immunoglobulins Variation</font>==
 
{| border="3" cellpadding="8"
 
{| border="3" cellpadding="8"

Revision as of 16:58, 4 September 2008

WikiBloodWikiBlood Banner.png
IMMUNOGLOBULINS
WIKIBLOOD FLASHCARDS


Immunoglobulins Structure and Function

Question Answer Article
What are immunoglobulins also known as?
  • Antibodies
 Link to Answer Article
How many domains does the heavy chain have?
  • 1 variable domain
  • 3 or 4 constant domains
 Link to Answer Article
How many domains does the light chain have?
  • 1 variable domain
  • 1 constant domain
 Link to Answer Article
What are hypervariable domains?
  • Folded pockets of the variable domain into which antibody can bind
  • Different antibodies have different amino acid sequences within the three variable domains
 Link to Answer Article
What does Fab stand for and from which chain is it generated?
  • Fragment associated with antigen binding
  • Light chain
 Link to Answer Article
What does Fc stand for and from which chain is it generated?
  • Constant fragment
  • Heavy chain
 Link to Answer Article
What does the Fc fragment do?
  • Mediates phagocytosis
  • Triggers inflammation
  • Targets Ig to certain tissues
 Link to Answer Article
What are the four major effects of antibodies?
  • Blockage and agglutination
  • Promotion of phagocytosis
  • Degranulation of mast cells/eosinophils
  • Complement Fixation
 Link to Answer Article



Classes of Immunoglobulin

Question Answer Article
How do the five classes of immunoglobulins vary from each other?
  • They each have a different composition to their heavy chains
 Link to Answer Article
IgA is specially adapted for function at which type of surface?
  • Mucosal surfaces
 Link to Answer Article
True or False: IgA is a monomer
  • False
  • IgA is a dimer
 Link to Answer Article
What are the functions of IgA?
  • Prevents agents from adhering to the epithelial surfaces as it binds to foreign antigen
  • Resists proteolytic digestion so can function in the gut
  • Does not activate the complement system so helps to preserve mucosal integrity
 Link to Answer Article
In which species has IgD been identified?
  • Ruminants
  • Pigs
  • Dogs
  • Rodents
 Link to Answer Article
What is the main function of IgD?
  • Helps B cell development
 Link to Answer Article
True or False: IgE is not a soluble antibody?
  • True
 Link to Answer Article
What are the functions of IgE?
  • Triggers acute inflammation by causing degranulation
  • Involved in type I hypersensitivity reactions
  • Involved in producing immunity to parasitic worms and nematode parasites
 Link to Answer Article
True or False: IgG is the smallest antibody and can easily leave the plasma and enter tissue?
  • True
 Link to Answer Article
Where is IgG produced?
  • Bone marrow
  • Spleen
  • Lymph nodes
 Link to Answer Article
What is the function of IgG?
  • Activates the classical pathway of the complement cascade
  • Can act as targets for macrophages, eosinophils and neutrophils
  • Causes agglutination and opsonisation of bacteria
 Link to Answer Article

START HERE TOMORROW WITH IG M



Immunoglobulins Variation

Question Answer Article
What are immunoglobulins also known as?
  • Antibodies
 Link to Answer Article



BACK TO THE IMMUNOGLOBULINS
BACK TO WIKIBLOOD FLASHCARDS
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