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*Cessation of [[Respiratory System General Introduction - Pathology#Mucociliary escalator|ciliary clearance]] and epithelial necrosis predisposes to secondary bacterial infections -> cough
 
*Cessation of [[Respiratory System General Introduction - Pathology#Mucociliary escalator|ciliary clearance]] and epithelial necrosis predisposes to secondary bacterial infections -> cough
 
*May cause [[Respiratory Viral Infections - Pathology#Parainfluenza- 3|rhinitis]] of cattle
 
*May cause [[Respiratory Viral Infections - Pathology#Parainfluenza- 3|rhinitis]] of cattle
*With other agents causes [[Respiratory Bacterial Infections - Pathology#Enzootic pneumonia of calves|calf pneumonia ]]
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**Together with managemental factors (overcrowding, poor ventilation, high humidity, deprivation of colostrum and stress caused by transport or mixing of stock)
   
====Diagnosis====
 
====Diagnosis====
 
*Diseased lung tissue from dead animals or centrifuged cells from lung lavage
 
*Diseased lung tissue from dead animals or centrifuged cells from lung lavage
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**Temperature sensitive mutant that replicates at 34<sup>o</sup>C but not at 37<sup>o</sup>C
 
**Temperature sensitive mutant that replicates at 34<sup>o</sup>C but not at 37<sup>o</sup>C
 
**Re-infection is common
 
**Re-infection is common
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====Secondary Concerns====
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*With other agents causes [[Respiratory Bacterial Infections - Pathology#Enzootic pneumonia of calves|calf pneumonia ]]
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*Associated with poor management:
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**Overcrowding
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**Poor ventilation
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**High humidity
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**Deprivation of colostrum
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**Stress caused by transport or mixing of stock
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