Hepatic Encephalopathy

Description

Hepatic encephalopathy is charaterised by a complex of neurological abnormalities that may occur in the presence of advanced liver disease. By far the most common cause in dog and cat is Portosystemic Shunt.

Diagnosis

Clinical Signs

Dog

Typical signs include:

• depression and lethargy
• aimless wandering
• head pressing
• blindness
• pacing
• coma
• poor growth rate
• anorexia
• gastrointestinal signs such as vomiting

Other signs include:

• temporary resolution of clinical signs with antimicrobial therapy
• prolonged recovery from sedation or anaesthesia
• polyuria and polydipsia in a third of cases

Cat

Typical signs include:

• well grown and in good body condition which in contrast to dogs
• hypersalivation or ptyalism is the most commonly reported clinical feature, but rarely in dogs
• seizures reported in 50% of cases, but uncommon in dogs
• anorexia, vomiting and diarrhoea, polyuria and polydipsia is less common
• compulsive behaviour is less common compared to in dogs

Laboratory Tests

Biochemistry

• Hypoproteinaemia
• Mild to moderate increase in alanine aminotransferase (ALT) and alkaline phosphatase (ALP)
• Decreased blood urea nitrogen (BUN)
• Hypoglycaemia in a small number of dogs

Other Tests

• Fasting hyperammonaemia
• Increased postprandial ± preprandial bile acids

Diagnostic Imaging

• Abdominal radiographs shows microhepatica and often renomegaly. Renomegally may relate to altered splanchnic blood flow or o increased metabolic activity of the kidney due to hyperammonaemia. These findings in a young dog is highly suggestive of Portosystemic Shunt.
• Confirmation of a Portosystemic Shunt requires visualisation of the shunting blood vessel. This may be done with either ultrasonography or contrast portography or at surgery.

Treatment

Surgical management

• Surgical ligation of shunt is recommended in cases of Portosystemic Shunt.

Medical management

• Enemas to decrease the amount of bacteria in the colon.
• Oral antibiotics such as ampicillin, neomycin or metronidazole can be given initially reduce the amount of bacteria in intestines and hence decrease the production of ammonia.
• Lactulose PO
  • This is a synthetic disaccharide which is metabolised by the colonic bacteria, acidifying the colon. Ammonia is converted into ammonium ions which cannot be absorbed, hence trapped in the colon and excreted in the faeces. Lactulose also acts as a osmotic laxative, allowing more faeces and bacteria to be washed out.
• A high carbohydrate, low protein (2g/kg/day) and low fat diet is recommended.
  • The aim is to provide adequate nutrients and energy to support hepatic tissue repair, reduce the metabolic load on the liver and minimise the development of hepatic encephalopathy

References

• Ettinger, S.J. and Feldman, E. C. (2000) Textbook of Veterinary Internal Medicine Diseases of the Dog and Cat Volume 2 (Fifth Edition) W.B. Saunders Company.
• Nelson, R.W. and Couto, C.G. (2009) Small Animal Internal Medicine (Fourth Edition) Mosby Elsevier.